نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار، فیزیولوژی ورزشی، گروه علوم ورزشی، دانشگاه قم، قم، ایران
2 کارشناس ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشگاه قم، قم، ایران
چکیده
شناسه دیجیتال (DOR):
98.1000/1735-0905.1398.36.59.99.1.1578.1606
پیشگیری و درمان دیابت با توجه به شیوه زندگی امروزه که با عدم تحرک، استرس و عادات غذایی نادرست همراه است، بسیار ضروریست. بنابراین هدف این پژوهش بررسی تأثیر تعاملی مصرف مکمل تخم گشنیز و تمرین منتخب هوازی بر برخی از عوامل خطرزایی قلبی-عروقی زنان مبتلا به دیابت نوع دو دارای اضافه وزن بود. در این مطالعه نیمه‌تجربی تعداد 40 زن دیابتی نوع دو دارای اضافه وزن با میانگین سن 6/4±82/48 به‌صورت تصادفی در گروه‌های تمرین هوازی+ مکمل گشنیز، تمرین هوازی+ دارونما، مکمل گشنیز و دارونما قرار گرفتند. برنامه تمرین هوازی شامل هشت هفته دویدن با شدت 60 تا 72 درصد ضربان قلب بیشینه بود. گروه‌های دریافت‌کننده مکمل، روزانه 500 میلی‌گرم پودر تخم گشنیز را 30 تا 60 دقیقه قبل از صرف وعده ناهار و شام مصرف می‌کردند. نمونه‌های خونی در مراحل پیش و پس آزمون جمع‌آوری و تحلیل داده‌ها با استفاده از آزمون آنالیز واریانس یک‌طرفه و آزمون تی وابسته با سطح معنی‌داری (0.05≥P) با استفاده از نرم‌افزار SPSS انجام شد. نتایج تحلیل درون گروهی نشان داد که سطوح سرمی کلسترول و LDL-C در گروه‌های تمرین-مکمل کاهش معنی‌داری یافت و سطح تری‌گلیسیرید و HDL-C در هیچ‌یک از گروه‌ها تغییر معنی‌داری نداشت. همچنین تفاوت معنی‌دار بین گروهی در هیچ‌یک از متغیر‌ها مشاهده نشد. نتایج بدست‌آمده از این پژوهش نشان داد هشت هفته مصرف مکمل گشنیز و تمرین هوازی می‌تواند اثرهای مفیدی بر روی سطح کلسترول و LDL-C در بیماران مبتلا به دیابت نوع دو داشته باشد، در نتیجه با تأثیری که بر چربی‌های خون می‌گذارد ممکن است باعث کاهش خطر بیماری‌های قلبی-عروقی شود.
کلیدواژه‌ها
- Aggarwala, J., Sharma, S., Jain, A. and Sarkar, A., 2016. Effects of aerobic exercise on blood glucose levels and lipid profile in Diabetes Mellitus type 2 subjects. Al Ameen Journal of Medical Sciences, 9(1): 65-69.
- Aghasi, M., Ghazi-Zahedi, S., Koohdani, F., Siassi, F., Nasli-Esfahani, E., Keshavarz, A. and Sotoudeh, G., 2018. The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial. BMC Complementary and Alternative Medicine, 18(1): 18.
- AminiLari, Z., Fararouei, M., Amanat, S., Sinaei, E., Dianatinasab, S., AminiLari, M., Daneshi, N. and Dianatinasab, M., 2017. The effect of 12 weeks aerobic, resistance, and combined exercises on omentin-1 levels and insulin resistance among type 2 diabetic middle-aged women. Diabetes and Metabolism Journal, 41(3): 205-212.
- Azimidokht, S.M.A., Mogharnasi, M., Kargar Shouroki, M.Kh. and Zarezade Mehrizi, A.A., 2015. The effect of 8 weeks interval training on insulin resistance and lipid profiles in type 2 diabetic men treated with metformin. Journal of Sport Biosciences, 7(3): 461-476.
- Bello, A.I., Owusu-Boakye, E., Adegoke, B.O.A. and Adjei, D.N., 2011. Effects of aerobic exercise on selected physiological parameters and quality of life in patients with type 2 diabetes mellitus. International Journal of General Medicine, 4: 723-727.
- Bijeh, N. and Hejazi, K., 2018. The effect of aerobic exercise on levels of HS-CRP, insulin resistance index and lipid profile in untrained middle-aged women. Razi Journal of Medical Sciences, 24(10): 1-11.
- Buse, J.B., Tan, M.H., Prince, M.J. and Erickson, P.P., 2004. The effects of oral anti‐hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes. Diabetes, Obesity and Metabolism, 6(2): 133-156.
- Chao, M., Zou, D., Zhang, Y., Chen, Y., Wang, M., Wu, H., Ning, G. and Wang, W., 2009. Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. Endocrine, 36(2): 268-274.
- Chien, K.L., Chen, M.F., Hsu, H.C., Su, T.C. and Lee, Y.T., 2009. Sports activity and risk of type 2 diabetes in Chinese. Diabetes Research and Clinical Practice, 84(3): 311-318.
- Chithra, V. and Leelamma, S., 1997. Hypolipidemic effect of coriander seeds (Coriandrum sativum): mechanism of action. Plant Foods for Human Nutrition, 51(2): 167-172.
- Dhanapakiam, P., Joseph, J.M., Ramaswamy, V.K., Moorthi, M. and Kumar, A.S., 2007. The cholesterol lowering property of coriander seeds (Coriandrum sativum): mechanism of action. Journal of Environmental Biology, 29(1): 53-56.
- Fritz, T. and Rosenqvist, U., 2001. Walking for exercise? Immediate effect on blood glucose levels in type 2 diabetes. Scandinavian Journal of Primary Health Care, 19(1): 31-33.
- Ghayur, M.N., Gilani, A.H., Afridi, M.B. and Houghton, P.J., 2005. Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascular Pharmacology, 43(4): 234-241.
- Ghiasvand Mohammadkhani, P., Irandoust, Kh., Taheri, M., Mirmoezzi, M. and Baić, M., 2019. Effects of eight weeks of aerobic exercise and taking caraway supplement on C-reactive protein and sleep quality in obese women. Biological Rhythm Research, 1-9.
- Herbert, A.J., Williams, A.G., Hennis, P.J., Erskine, R.M., Sale, C., Day, S.H. and Stebbings, G.K., 2019. The interactions of physical activity, exercise and genetics and their associations with bone mineral density: implications for injury risk in elite athletes. European Journal of Applied Physiology, 119(1): 29-47.
- Hughes, S., 2003. Novel cardiovascular risk factors. Journal of Cardiovascular Nursing, 18(2): 131-138.
- Kadoglou, N.P., Perrea, D., Iliadis, F., Angelopoulou, N., Liapis, C. and Alevizos, M., 2007. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care, 30(3): 719-721.
- Karimi, E., Gholami, J., Rezaei, P. and Mazidi, M., 2015. The effect of oral coriander seed extracts on lipids, blood glucose, and oxidative stress indicators in streptozotocin-induced diabet. Qom University of Medical Sciences Journal, 8(5): 85-92.
- Kelley, D.E. and Goodpaster, B.H., 2001. Effects of exercise on glucose homeostasis in type 2 diabetes mellitus. Medicine and Science in Sports and Exercise, 33(6 Suppl), S495-501.
- Khan, A., Safdar, M., Ali Khan, M.M., Khattak, K.N. and Anderson, R.A., 2003. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care, 26(12): 3215-3218.
- Kraemer, W.J., Fleck, S.J. and Deschenes, M.R., 2011. Exercise Physiology: Integrating Theory and Application. Lippincott Williams & Wilkins, 488p.
- Lo Cantore, P., Iacobellis, N.S., De Marco, A., Capasso, F. and Senatore, F., 2004. Antibacterial activity of Coriandrum sativum L. and Foeniculum vulgare Miller var. vulgare (Miller) essential oils. Journal of Agricultural and Food Chemistry, 52(26): 7862-7866.
- Mackenzie, R., Maxwell, N., Castle, P., Brickley, G. and Watt, P., 2011. Acute hypoxia and exercise improve insulin sensitivity (SI2*) in individuals with type 2 diabetes. Diabetes/Metabolism Research and Reviews, 27(1): 94-101.
- Mahmoudi, Y., Gholami, M., Nikbakht, H., Ebrahim, K. and Bakhtiyari, S., 2018. Effect of high intensity interval training with metformin on lipid profiles and HbA1c in diabetic rats. Iranian Journal of Diabetes and Obesity (IJDO), 10(3): 144-150.
- Marandi, S.M., Abadi, N.G., Esfarjani, F., Mojtahedi, H. and Ghasemi, G., 2013. Effects of intensity of aerobics on body composition and blood lipid profile in obese/overweight females. International Journal of Preventive Medicine, 4(Suppl 1), S118-125.
- Mayer-Davis, E.J., D'Agostino J.r., R., Karter, A.J., Haffner, S.M., Rewers, M.J., Saad, M. and Bergman, R.N., 1998. Intensity and amount of physical activity in relation to insulin sensitivity: the insulin resistance atherosclerosis study. Jama, 279(9): 669-674.
- Nayebifar, S.H., Afzalpour, M.E., Saghebjoo, M., Hedayati, M. and Shirzaee, P., 2012. The effect of aerobic and resistance trainings on serum C-Reactive Protein, lipid profile and body composition in overweight women. Modern Care Journal, 8(4): 186-196.
- Nieman, D.C., Brock, D.W., Butterworth, D., Utter, A.C. and Nieman, C.C., 2002. Reducing diet and/or exercise training decreases the lipid and lipoprotein risk factors of moderately obese women. Journal of the American College of Nutrition, 21(4): 344-350.
- Oberbach, A., Tönjes, A., Klöting, N., Fasshauer, M., Kratzsch, J., Busse, M.W., Paschke, R., Stumvoll, M. and Blüher, M., 2006. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. European Journal of Endocrinology, 154(4): 577-585.
- Parsaeyan, N., 2012. The effect of coriander seed powder consumption on atherosclerotic and cardioprotective indices of type 2 diabetic patients. Iranian Journal of Diabetes and Obesity (IJDO), 4(2): 86-90.
- Pollock, M.L., Gaesser, G.A., Butcher, J.D., Després, J.P., Dishman, R.K., Franklin, B.A. and Garber, C.E., 1998. ACSM position stand: the recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Medicine and Science in Sports and Exercise, 30(6): 975-991.
- Puglisi, M.J., Vaishnav, U., Shrestha, S., Torres-Gonzalez, M., Wood, R.J., Volek, J.S. and Fernandez, M.L., 2008. Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines. Lipids in Health and disease, 7(1): 14p.
- Shaw, I., Shaw, B.S. and Krasilshchikov, O., 2009. Comparison of aerobic and combined aerobic and resistance training on low-density lipoprotein cholesterol concentrations in men. Cardiovascular Journal of Africa, 20(5): 290-295.
- Shimomura, I., Funahashi, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., Tokunaga, K. and Matsuzawa, Y., 1996. Enhanced expression of
PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nature medicine, 2(7): 800-803.
PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nature medicine, 2(7): 800-803.
- Sjøberg, K.A., Frøsig, C., Kjøbsted, R., Sylow, L., Kleinert, M., Betik, A.C., Shaw, C.S., Kiens, B., Wojtaszewski, J.F.P., Rattigan, S., Richter, E.A. and McConell, G.K., 2017. Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling. Diabetes, 66(6): 1501-1510.
- Sushruta, K., Satyanarayana, S., Srinivas, S. and Sekhar, J.R., 2006. Evaluation of the blood-glucose reducing effects of aqueous extracts of the selected umbelliferous fruits used in culinary practices. Tropical Journal of Pharmaceutical Research, 5(2): 613-617.
- Takeda, H., Sadakane, C., Hattori, T., Katsurada, T., Ohkawara, T., Nagai, K. and Asaka, M., 2008. Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology, 134(7): 2004-2013.
- Tanaka, H., Monahan, K.D. and Seals, D.R., 2001. Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology, 37(1):
153-156.
153-156.
- Tarighat Esfanjani, A., Namazi, N. and Bahrami, A., 2012. Effect of hydro-alcoholic nettle extract on lipid profiles and blood pressure in type 2 diabetes patients. Iranian Journal of Endocrinology and Metabolism, 13(5): 449-458.
- Tyler, V.E., Brady, L.R. and Robbers, J.E., 1988. Pharmacognosy. Lea and Fabiger, Philadelphia, 537p.
- Uusitupa, M.I., Niskanen, L.K., Siitonen, O., Voutilainen, E. and Pyörälä, K., 1993. Ten-year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in type 2 (non-insulin-dependent) diabetic and non-diabetic subjects. Diabetologia, 36(11): 1175-1184.
- Weber, N., Schönwiese, S., Klein, E. and Mukherjee, K.D., 1999. Adipose tissue triacylglycerols of rats are modulated differently by dietary isomeric octadecenoic acids from coriander oil and high oleic sunflower oil. The Journal of Nutrition, 129(12): 2206-2211.
- Yavari, A., Najafipour, F., Aliasgharzadeh, A., Niafar, M. and Mobasseri, M., 2012. Effect of aerobic exercise, resistance training or combined training on glycaemic control and cardiovascular risk factors in patients with type 2 diabetes. Biology of Sport, 29(2): 135-143.
- Zamani, A., Akbarpour Beni, M. and Assar Zadeh Noosh Abadi, M., 2012. Relationship between body composition with blood lipids profile. European Journal of Experimental Biology, 2(5): 1509-1513.
- Zhang, Q., Köhler, M., Yang, S.N., Zhang, F., Larsson, O. and Berggren, P.O., 2004. Growth hormone promotes Ca2+-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation. Molecular Endocrinolo, 18(7): 1658-1669.
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