Document Type : Research Paper
Authors
1 Cell & molecular research center, Faculty of Medicine, Ahwaz Jundi-Shapour University of Medical Sciences, Ahwaz, Iran
2 Department of Anatomical Sciences, Faculty of Medicine, Ahwaz Jundi-Shapour University of Medical Sciences, Ahwaz, Iran
Abstract
Regarding highly prescription of medicines, in recent years, herbal effects on prevention and treatment of toxicity induced by various drugs have received a great deal of attention. After water, tea is the most widely consumed beverage in the world. Green tea (Camellia sinensis L.) has antioxidant and detoxification activities. In this study protective effect of green tea extract on hepaotoxicity induced by acetaminophen has been evaluated. 32 male mice were randomly divided into 4 groups. Control group received only normal saline. Green tea extract group was fed by 7mg/l green tea extract for 30 days. 500 mg/kg acetaminophen was administrated to acetaminophen group. Experimental group recieved 7mg/l green tea extract for 30 days and a single dose of 500 mg/kg acetaminophen prescribed in 29th day. In 31st day blood samples were taken from jugular arteries for biochemical tests. Then the liver placed in 10% formalin for histopathology assessments. ALT (Alanin Teransferase) and AST (Aspartate Teransferase) reduced significantly in experimental group (p<0.05). Histopathology assessments showed that necrosis of liver, congestion of blood cells and accumulation of inflammatory cells also reduced in experimental group compared to acetaminophen treated mice. These finding suggest that Green tea extract might have protective effect on liver damage induced by acetaminophen.
Keywords
)