Gh. Naderi; N. Jafari Dinani; N. Nejabat; M. Kelardasht; A. Jafarian Dehkordi; S. Asgary; R. Shami
Abstract
Disturbance in haemostatic system causes abnormal clots in vessels and thromboambolia. Streptokinas and urokinas are used for emergency treatment of thromboambolia. These drugs have certain limitations which cause serious and sometimes fatal consequences. Herbal preparations are considered to be safe ...
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Disturbance in haemostatic system causes abnormal clots in vessels and thromboambolia. Streptokinas and urokinas are used for emergency treatment of thromboambolia. These drugs have certain limitations which cause serious and sometimes fatal consequences. Herbal preparations are considered to be safe and without side-effects. Since in ancient times it was reported that Zataria moltiflora Boiss., Curcuma domestica Valet., Cinnamomum verum J.Presl and Heracleum persicum Desf. Ex Fischer present anticoagulant effects. This study performed to evaluate fibrinolytic effects of these plants. To evaluate fibrinolytic effects, labeled fibrinogen with FITC and Ca2+ was added to human plasma. Polyphenolic extracts (0.05, 0.5, 5, 50mg/ml) without and with streptokinas, were added to labeled clot. Fluorescence was determined after 10, 20, 40 and 60 minutes (Ex=478, Em= 510). Our findings show that extract of Zataria moltiflora, Curcuma domestica and Cinnamomum verum reveal fibrinolytic effects (P<0.05). This effects are significant and dose dependable, but Heracleum persicum had no significant fibrinolytic effect (P>0.05). Fibrinolytic effects of streptokinase in presence Zataria moltiflora are increased significantly and dose dependably. This effect in presence of Curcuma domestica and Cinnamon only in 5 and 50 mg/dl are increased. Heracleum persicum does not affect fibrinolytic properties of streptokinase. The present study indicate that, Zataria moltiflora presents best fibrinolytic effect, then Curcuma domestica and Cinnamon verum respectively reveal significant fibrinolytic effect and could lysis blood clots in vitro. Consequently, we suggest that further studies to determine in vivo clot dissolving properties and active component(s) of these herbs for clot lysis are warranted.
S. Asgary; N. Jafari Dinani; A.R. Ghanadi; A.R. Helalat
Volume 24, Issue 1 , May 2008, , Pages 66-73
Abstract
Hypercholesterolaemia is among the most common health problems treated with traditional remedies. Nigella sativa is an effective plant for hypercholesterolemia treatment. However the effect of this herb on hematologic factors and hemostase system has not been elucidated. This study was designed to investigate ...
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Hypercholesterolaemia is among the most common health problems treated with traditional remedies. Nigella sativa is an effective plant for hypercholesterolemia treatment. However the effect of this herb on hematologic factors and hemostase system has not been elucidated. This study was designed to investigate the effect of Nigella sativa on these factors in both normal and hypercholestderolemic rabbits. In this research, twenty rabbits were randomly distributed into four groups of five each. Having normal diet and normal diet + Nigella sativa (5٪), hypercholesterolemic diet (1٪) and hypercholesterolemic diet + Nigella sativa groups. Animal groups received their own diets and water and libitum for a period of 8 weeks. The results indicate that Nigella sativa diet only significantly increase numbers of platelet and do not effect on white and red blood cell, hemoglobin, hematocrit and VII factors. Dietary use of Nigella sativa except increasing platelet number that may be causes increase coagulation don’t have effect on other hematologic factors. Thus these results call for more research on effect of different diet (hypercholesterolemic and normal diet) supplemented with Nigella sativa on different coagulation factors and hemostase system.
N. Jafari Dinani; S. Asgary; H. Madani; Gh. Naderi; P. Mahzoni
Volume 23, Issue 1 , May 2007, , Pages 1-12
Abstract
Atherosclerosis occurs principally in medium and large arteries and is a leading cause of cardiovascular disease. Epidemiologic study indicates that coronary heart disease and atherosclerosis is less in societies which use herbal medicines. Glycyrrhiza glabra is an herb of Papilionaceae family which ...
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Atherosclerosis occurs principally in medium and large arteries and is a leading cause of cardiovascular disease. Epidemiologic study indicates that coronary heart disease and atherosclerosis is less in societies which use herbal medicines. Glycyrrhiza glabra is an herb of Papilionaceae family which contains hypolipidemic compounds and flavonoids with high antioxidant properties. This study was conducted to determine the effect of Glycyrrhiza glabra extract on blood lipid levels and atherosclerosis in rabbits fed with high cholesterol diet. Fifteen male rabbits were randomly divided into three groups, normal diet group, highcholesterolemic control group (1% cholesterol) and high-cholesterol + Glycyrrhiza glabra group (50 mg/kg body weight every other day). The concentration of total cholesterol (TC), LDL cholesterol, triglycerides (TG) and HDL cholesterol were determined in rabbits in the beginning of experiment, and in the end of the first and second month of the study. In the end of the experimental period the rabbits were killed having overdose chloroform and their aortas were removed for assessing atherosclerotic plaques. Results showed that Glycyrrhiza glabra decreased TC, LDL and TG levels and increased HDL, significantly. The lesion atherosclerotic significantly reduced in high-cholesterol + Glycyrrhiza glabra group as compared to highcholesterolemic control group. It could be suggested that the Glycyrrhiza glabra extract can effectively prevent the progress of atherosclerosis and extensive studies are needed to investigate the effect of Glycyrrhiza glabra in prevention and treatment of atherosclerosis.
S. Asgary; H. Madani; P. Mahzoni; N. Jafari; Gh. Naderi
Volume 22, Issue 4 , February 2007, , Pages 303-314
Abstract
Coronary heart disease (CHD) is invariably the most frequent cause of death in most of the west countries. Atherosclerosis which is the most common risk factor for CHD caused by a gradual deposition of fats and lipids in muscular arteries. Many species of Artemisia from Compositeae family have hypolipidemic ...
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Coronary heart disease (CHD) is invariably the most frequent cause of death in most of the west countries. Atherosclerosis which is the most common risk factor for CHD caused by a gradual deposition of fats and lipids in muscular arteries. Many species of Artemisia from Compositeae family have hypolipidemic and antioxidative properties. The objective of this study was to determine the effect of Artemisia sieberi extract on blood lipids and development of atherosclerosis in rabbits fed by a high cholesterol diet. For this objective 15 male rabbits were randomly divided in three groups (normal diet, hypercholesterolemic diet (HCD) and HCD + 100 mg/kg body weight Artemisia sieberi extract). Total cholesterol (TC), LDL cholesterol, triglycerides (TG) and HDL cholesterol were measured before starting and after 1st and 2nd months of experimental period. After two months, rabbits were killed following chloroform over dose and their aortas were removed for assessment of atherosclerotic plaques. The results indicate that Artemisia sieberi significantly reduces the levels of TC, LDL, TG and TC/HDL and significantly increase the level of HDL. The atherosclerotic plaque formation was significantly reduced in Artemisia sieberi group as compared to the control hypercholesterolemic group.
