Iranian Journal of Medicinal and Aromatic Plants Research

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Antioxidant and free radical scavenging activity of methanolic extract of Pterocarya fraxinifolia (Lam.) Spach leaves and bark

Document Type : Research Paper

Authors

Pharmaceutical Sciences Research Center, School of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran

Abstract

Pterocarya fraxinifolia (Lam.) Spach (Juglandaceae) is widely distributed in northern area of Iran. Little information is available about its chemical composition and biological activity. In this paper, the antioxidant activity of Pterocarya fraxinifolia was determined. Bark and fresh leaves of Pterocarya fraxinifolia were collected from Dasht-e-Naz, Sari, Iran. Methanolc extract was used in different experiments. There was higher total phenol and flavonoid contents in leaves. IC50 for DPPH radical-scavenging activity was 15.59±0.09 for leaves and 166.24±2.30 mg ml-1 for bark, respectively.The leaves extract exhibited a good reducing power at 2.5 and 80 µg ml-1 that was comparable with ascorbic acid (p>0.05). The extracts also showed weak nitric oxide-scavenging activity and Fe2+ chelating ability. All tested extracts exhibited high antioxidant activity in peroxidation inhibition test. There were no significant differences (p>0.05) among extracts in antioxidative activity. All of extracts manifested almost the same pattern of activity as ascorbic acid and BHA at different incubation times (p>0.05). The leaves and bark extracts of Pterocarya fraxinifolia exhibited good but different levels of antioxidant activity in all the models studied. The extracts had good reducing power, anti-lipid peroxidation activity and DPPH radical-scavenging activity.

Keywords

References
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Iranian Journal of Medicinal and Aromatic Plants Research
Volume 24, Issue 3 - Serial Number 41
November 2008
Pages 374-384
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