Study of anti-inflammatory effect of aqueous and hexane extract of Apium graveolens L. in mice

Ramezani, M.; Nasri, S.; Yassa, N.

Document Type : Research Paper

Authors

¹ Department of Biology, Islamic Azad University, Ashtian Branch, Ashtian, Iran

² Department of Biology, Payam Noor University, Tehran and Avaj Centere, Iran

³ Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences and Medicinal Plant Research Center, Tehran, Iran

Abstract

medicine, in present study aqueous and hexane extracts were evaluated to find effective fractions. For induction of inflammation xylene-induced ear edema were used. Male NMRI mice were divided into three groups: positive control (dexamethason 15mg/kg), negative control (normal saline), and experimental groups. Experimental groups were injected by 100, 200, 300, 400 and 500mg/kg of aqueous and hexane extracts intraperitoneally. To find effective constituents of extract, TLC (thin layer chromatography) was performed. Results have shown significant anti-inflammatory effects of both extracts (100-500mg/kg doses) with control, and there was not significant difference with dexamethason. Data show potent anti-inflammatory effects of aqueous and hexane extracts even with low doses which may be due to existence of flavonoid, phthalid and coumarins in Apium graveolens seeds.

Keywords

References

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Iranian Journal of Medicinal and Aromatic Plants Research

Study of anti-inflammatory effect of aqueous and hexane extract of Apium graveolens L. in mice

References

References

Volume 24, Issue 4 - Serial Number 42
February 2009
Pages 437-443

Study of anti-inflammatory effect of aqueous and hexane extract of Apium graveolens L. in mice

References

References

Volume 24, Issue 4 - Serial Number 42February 2009Pages 437-443

Volume 24, Issue 4 - Serial Number 42
February 2009
Pages 437-443