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Comparison between Matricaria recutita L. aqueous and hydroalcholic extract on morphine withdrawal signs in the presence and absence of Tamoxifen

Document Type : Research Paper

Authors

1 Department of Biology, Shahid Chamran University of Ahvaz, Iran,

2 Ahvaz Jundishapur University of Medical Sciences, Iran

3 Department of Biology, Shahid Chamran University of Ahvaz, Iran

Abstract

Various studies indicated that the phytoestrogenic components exist in the Matricaria recutita L. Phytoestrogens act as a weak agonist and/or antagonist of estrogen receptors. On the other hand, it has been showed that the sex hormones affect dependency of narcotic drugs. In the present study the effect of aqueous and hydroalcholic extract of Matricaria recutita on morphine withdrawal signs in presence and/or absence of estrogen receptor antagonist were investigated. Male adult wistar rats weighing 240±30 gram classified in groups of seven were used. Morphine and naloxone were applied for dependence and withdrawal syndrome induction, respectively. Rearing, jumping and grooming were evaluated. Tamoxifen (0.5 mg/kg) as an estrogen antagonist was applied. High performance liquid chromatography (HPLC) was used for comparison between phytoestrogenic components of both extracts. Results showed that: 1) Hydroalcoholic extract of Matricaria recutita decreased rearing and grooming significantly but aqueous extract attenuated only rearing, therefore hydroalcoholic extract of MR had more sedative effect than the aqueous extract. 2) Tamoxifen prevented the MR induced rearing decline, but increased grooming sign in presence of both extract. 3) Tamoxifen increased jumping and grooming behaviors but decreased rearing sign. 4) HPLC showed the presence of apigenine and chrysin (phytoestrogenic components) in aqueous and hydroalcoholic extract of MR but the extraction amount of them was more in hydroalcoholic than the aqueous extract. It seems the phytoestrogenic components of both MR extracts induce sedative effect on some of morphine withdrawal behaviors and probably by interaction with some neurochemical systems of dependence phenomena in central nervous system.

Keywords

References
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Iranian Journal of Medicinal and Aromatic Plants Research
Volume 25, Issue 2 - Serial Number 44
August 2009
Pages 170-181
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