Document Type : Research Paper
Authors
Abstract
Rhabdomyolysis is an injury of skeletal muscle and it causes leakage of cellular contents including myoglobine. Myoglobinuria may produce acute renal failure due to the oxidative reactions. In the present study, the effect of silymarin and vitamin C (as natural antioxidant) was compared on myoglobinuric renal toxicity in rats after glycerol injection. This study was carried in 7groups of rats: Group 1: control, group 2: glycerol, group 3: glycerol + silymarin by injection, group 4: glycerol + silymarin and vitamin C by injection, group5: glycerol + vitamin C by injection, group 6: glycerol + silymarin by orally and group7: glycerol + vitamin C by orally. Serum of rats was isolated 24 hours after glycerol injection. Serum concentrations of BUN, creatinine, sodium and potassium were determined as renal function indexes. Also myoglobine, gama glutamyl transferase and alkaline phosphatase levels were measured by kit. According to the results, the glycerol caused muscular injury and significantly elevated myoglobine. This elevation was controlled by injection of vitamin C. The changes of other serum factors were better controlled by injection of vitamin C than that of silymarin. Myoglobinuric renal failure was modulated by oxidative stress as vitamin C showed a protective effect. However, Silymarin did not have any effects on muscular injury and renal toxicity while it was effective when co-administrated with vitamin C.
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