Effect of aqueous extract of Aloe vera L. on the expression of 75NTR and BDNF after spinal cord compression in adult rats

Heshmati, M.; Jalali Nadoushan, M.R.; Fakhrieh, Sh.

doi:10.22092/ijmapr.2015.11931

Document Type : Research Paper

Authors

¹ Department of Anatomy and Pathology, Shahed University, Tehran, Iran

² Medical Graduate, Shahed University, Tehran, Iran

https://doi.org/10.22092/ijmapr.2015.11931

Abstract

This research was aimed to evaluate the effects of aqueous extract of Aloe vera L., on motoneuron survival, P75^NTR and BDNF expression. Twenty-Four Sprague-Dawley rats were obtained from Razi Institute. They were divided into four groups:1-laminectomy ((T9-T11 vertebra)+injection of Aloe vera extract. 2- laminectomy+injection Aloe vera extract+compression. 3- laminectomy+injection of saline normal. 4- laminectomy+injection of normal saline + compression. Intraprituneal injection continued for four weeks. After four weeks, they were sacrificed. Spinal cord motoneurons were counted and their morphometry was studied. Expression P75^NTR and BDNF were analyzed by immunohistochemistry. Results showed that compression caused motoneurons reduction with hematoma among the cells and in cavitation. The aqueous extract of Aloe vera caused to decrease the motoneurons death and increase the BDNF expression (p ≤ 0.05). In the second group, despite increasing expression of P75NTR, motoneuron death decreased significantly (p ≤ 0.05) which may be due to the dual role of the receptor or various properties of Aloe vera. The immunomodulatory effect of Aloe vera and multiple action of P75 in survival or motoneuron death in different times of life were confirmed in this research.

Keywords

References

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Iranian Journal of Medicinal and Aromatic Plants Research

Effect of aqueous extract of Aloe vera L. on the expression of 75NTR and BDNF after spinal cord compression in adult rats

References

References

Volume 30, Issue 6 - Serial Number 68
February 2015
Pages 965-976

Effect of aqueous extract of Aloe vera L. on the expression of 75NTR and BDNF after spinal cord compression in adult rats

References

References

Volume 30, Issue 6 - Serial Number 68February 2015Pages 965-976

Volume 30, Issue 6 - Serial Number 68
February 2015
Pages 965-976