Effect of aqueous extract of sumac (Rhus coriaria L.) on the level of blood glucose and serum lipids in diabetic rats

Salimi, Z.; Headari, R.; Nejati, V.; Eskandary, A.; Ghasemi, Z.

doi:10.22092/ijmapr.2015.11920

Document Type : Research Paper

Authors

¹ Department of Biology, Faculty of Science, Urmia University, Urmia, Iran

² Faculty of Science, Razi University, Kermanshah, Iran

https://doi.org/10.22092/ijmapr.2015.11920

Abstract

Sumac is a shrub with a long history in traditional medicine and due to the phenolic compounds, it has been used as strong antioxidant in treatment of diseases. According to the importance of medicinal plants with the least side effects, in this study the aqueous extract of sumac (Rhus coriaria L.) was investigated to determine the antidiabetic effects. In this experiment, 30 adult male Wistar rats, with average weight of 180-230 g, were used, divided into 5 groups of 6 each. The rats in the control group were injected with physiological serum with the same volume of injection material. The rats in the second group were made diabetic by intraperitoneal injection of Alloxan monohydrate (120 mg/kgbw). In addition to the same treatment of the second group, the rats of third, fourth and fifth groups were orally treated by aqueous extract of sumac at 50, 100 and 250 mg/kgbw for four weeks. Blood glucose level was measured at the start of treatment and at the end of the second and fourth weeks. At the end of 28 days, rats were bled from the heart and total cholesterol, triglycerides, serum LDL-C and HDL-C were measured.Treatment with extract of sumac resulted in a significant reduction in blood glucose, triglyceride, cholesterol and serum LDL-C in comparison to diabetic group (p<0.05). Changes in serum HDL-C in the groups treated with the extract were not significant compared to diabetic group. Results showed that the aqueous extract of sumac in an experimental model of diabetes mellitus in rats caused appropriate changes in the level of blood glucose and serum lipids.

Keywords

References

- Adewole, S.O., Caxton-Martins, E.A. and Ojewole, J.A.O., 2007. Protective effect of quercetin on the morphology of pancreatic β cell of streptozotocin-treated diabetes rats. African Journal of Traditional, Complementary and Alternative medicines (AJTCAM), 4(1): 64-74.

- Anandh Babu, P.V., Sabitha, K.E. and Shyamaladevi, C.S., 2006. Green extract impedes dyslipidaemia and development of cardiac dysfunction in streptozotocin in diabetic rats. Clinical and Experimental Pharmacology and Physiology, 33(12): 1184-1189.

- Bors, W., Heller, W., Michel, C. and Saran, M., 1990. Flavonoids as antioxidants: determination of radical scavenging efficiencies. Methods in Enzymology, 186: 343-355.

- Giancarlos, R., Rosas, L.M., Nadjafi, F. and Francesco, M., 2006. Hypoglycaemic activity of two spices extract: Rhus coriaria L. and Bunium persicum Boiss. Natural Product Research: Formerly Natural Product Letters, 20(9): 882-886.

- Jayaprakasam, B., Vareed, S., Olson, L.K. and Nair, G.M., 2005. Insulin secretion by bioactive anthocyanins and anthocyanidins in fruits. Journal of Agricultural and Food Chemistry ,53: 28-31.

- Kato, A., Minoshima, Y., Yamamoto, J., Adachi, I., Watson, A.A. and Nash, R.J., 2008. Protective effect of dietary chamomile tea on diabetic complication. Journal of Agricultural and Food Chemistry, 56(17): 8206-8211.

- Kuzuya, T., Nakagawa, S., Satoh, J., Kanazawa, Y., Iwamoto, Y., Kobayashi, M., Nanjo, K., Sasaki, A., Seino, Y., Ito, C., Shima, K., Nonaka, K. and Kadowaki. T., 2002. Report of the committee on the classification and diagnosis criteria of diabetes mellitus. Diabetes Research and Clinical Practice, 55: 65-85.

- Li, W.L., Zheng, H.C., Bukuru, J. and Dekimpe, N., 2004. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology, 92: 1-21.

- Maritim, A.C., Sanders, R.A. and Watkins, J.B., 2003. Diabetes, oxidative stress and antioxidant: review. Journal of Biochemical and Molecular Toxicology, 17: 24-28.

- Mavlyanov, S.M., Islambekov, S., Karimdzhanov, A.K. and Imailov, A.I., 1997. Anthoctans and organic acids of the fruits of some species of sumac. Chemistry of Natural Compounds, (33): 279-280.

- NuralievIu, N.I. and Avezov, G.A., 1992. The efficacy of quercetin in alloxan diabetes. Eksperimental'naia i Klinicheskaia Farmakologiia, 55(1): 42-44.

- Ozcan, M., 2003. Antioxidant activities of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil. Journal of Medicinal Food, 6(3): 267-270.

- Ozcan, M. and Haciseferogullari, H., 2004. A condiment [sumac (Rhus coriaria L.) fruits]: some phsico-chemical properties. Bulgarian Journal of Plant Physiology, 30(3-4): 74-84.

- Perchellet, J.P., Gali, H.U., Perchellet, E.M., Klish, D.S. and Armbrust, A.D., 1992. Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin. Basic Life Sciences, 59: 783-801.

- Pourahmad, J., Eskandari, M.R., Shkibaei, R. and Kamalinejad, M., 2010. A search for hepatoprotective activity of aqueous extract of Rhus coriaria L. against oxidative stress cytotoxicity. Food and Chemical Toxicology, 48(3): 854-858.

- Raufi, A., Mardani, M., Sabagh, M., Delfan, B. and Tarahi, M.J., 2009. A study on effect of Rhus coriaria (Sumac) on LDL Cholesterol level compared with Lovastatin. Journal of Ilam University of Medical Sciences, 17(3): 51-56.

- Ricardo, K.F.S., Oliveria, T.T., Nagem, T.J., Pinto, A.S., Oliveira, M.G.A. and Soares, J.F., 2001. Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton. Brazilian Archives of Biology and Technology, 44 (3): 263-267.

- Sabu, M.C. and Kuttan, R., 2002. Antidiabetic activity of medicinal plants and its relationship with their antioxidants property. Journal of Ethnopharmacology, 81(2): 155-160.

- Saravanan, R. and Pari, L., 2005. Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan inducedhyperglycemic rats. BMC Complementary and Alternative Medicine,
5: 14.

- Suji, G. and Sivakami, S., 2003. Approaches to the treatment of diabetes mellitus: an overview. Cellular and molecular biology (Noisy-le-Grand, France), 49(4): 635-639.

- Tripathi, B.K. and Srivastava, A.K., 2006. Diabetes mellitus: complication and therapeutics. Medical Science Monitor, 12(7): RA130-147.

- Wandell, P.E., 2005. Quality of life patients with diabetes mellitus. An overview of research in primary health care in the Nordic countries. Scandinavian Journal of Primary Health Care,
23(2): 68-74.

- Yanardag, R., Bolkent, S., Ozsoy-Sacan, O. and Karabulut-Bulan, O., 2002. The effect of chard (Beta vulgaris L. var. cicla) extract on the kidney tissue, serum urea, and creatinine levels of diabetic rats. Phytotherapy Research, 16: 758-761.

- Zargham, H. and Zargham, R., 2008. Tannin extracted from sumac inhibits vascular smooth muscle
cell migration. McGill Journal of Medicine, 11(2):119-123.

Iranian Journal of Medicinal and Aromatic Plants Research

Effect of aqueous extract of sumac (Rhus coriaria L.) on the level of blood glucose and serum lipids in diabetic rats

References

References

Volume 30, Issue 6 - Serial Number 68
February 2015
Pages 843-851

Effect of aqueous extract of sumac (Rhus coriaria L.) on the level of blood glucose and serum lipids in diabetic rats

References

References

Volume 30, Issue 6 - Serial Number 68February 2015Pages 843-851

Volume 30, Issue 6 - Serial Number 68
February 2015
Pages 843-851