In collaboration with Scientific Association of Iranian Medicinal Plants

Document Type : Research Paper

Authors

1 Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

2 M.Sc. student, Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

3 B.Sc. student, Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

Abstract

Renal stones is a common disease of the urinary tract that many people suffer from it. Although there are many herbal and chemical drugs for the prevention and treatment of kidney stones in recent years, there is no effective and safe drug treatment that can lead to complete treatment and prevention of these diseases. Today, the use of herbal products is considered by researchers because of the harmful and side effects of chemical drugs. This research was carried out with the purpose of determining the herbal tea effect of leaf and stem of Apium graveolens L. and Kelussia odoratissima odoratissima Mozaff. on the formation and dissolution of calcium oxalate. In order to study the dissolution and precipitation of calcium oxalate salt, electrochemical and classic analytical methods were used. The experimental results of complexometery and conductometery techniques reveal that these herbal teas have a good effect on the dissolution and prevention of formation of calcium oxalate stone (P<0.05). According to the findings of this study, these herbal teas could be a good choice for treatment diseases and to prevent calcium oxalate formation in people disposed to kidney stones.

Keywords

- Atmani, F. and Khan, S., 2000. Effect of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro. BJU International, 85: 621-625.
- Bard, A. and Faulkner, L., 2001. Electrochemical Methods: Fundamentals and Applications. John Wiley & Sons, 865p.
- Barzgarnejad, A., Azadbakht, M., Emadian, O. and Fattahi, M., 2009. In vitro effect of juniper fruit extract on dissolution of urinary stones. Journal of Mazandaran University of Medical Sciences, 20(75): 31-36.
- Chiej, R., 1984. Encyclopaedia of Medicinal Plants. MacDonald, London, 447p.
- Chitra, V., Gowri, K. and Udayasri, N., 2012. Antilithiatic activity of alcoholic extract of Boerhaavia diffusa roots on ethylene glycol induced lithiasis in rats. International Journal of Pharmacy and Pharmaceutical Sciences, 4(2): 149-153.
- Das, I., Guptaa, S.K., Pandey, V.N. and Ansari, S.A., 2004. Inhibition and dissolution of calcium oxalate crystals by Berberis vulgaris-Q and other metabolites. Journal of Crystal Growth, 267: 654-661.
- Frackowiak, A., Skibiński, P., Gaweł, W., Zaczyńska, E., Czarny, A. and Gancarz, R., 2010. Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compoundsin kidney stone therapy. European Journal of Medicinal Chemistry, 45: 1001-1007.
- Grases, F., Prieto, R.M., Gomila, I., Sanchis, P. and Costa-Bauzá, A., 2009. Phytotherapy and renal stones: the role of antioxidants. a pilot study in wistar rats. Journal of Urology and Research, 37(1): 35-40.
- Kalpana, S., Nirmaladevi, R., Shrinidhi, T. and Karthika, P., 2013. Inhibition of calcium oxalate crystallization in vitro by extract of banana cultivar Monthan. International Journal of Pharmacy and Pharmaceutical Sciences, 5(4): 649-653.
- Khajavirad, A., Hadjzadeh, M.A.R., Monavvar, N. and Ayathollahi, H., 2008. The preventive effects of ethyl acetate fractions from aqueous and ethanolic extract of Nigella sativa L. seeds on calcium oxalate stones in wistar rat. Journal of Semnan University of Medical Sciences, 9(2): 123-130.
- Khan, S.R. and Thamilselvan, S., 2000. Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals. Molecular Urology, 4: 305-312.
- Launert, E., 1981. Edible and Medicinal Plants. Hamlyn, London, 288.
- Lee, T.F., Lin, Y.L. and Huang, Y.T., 2007. Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta Medica, 73(6): 527-534.
- Li, P., Jia, J., Zhang, D., Xie, J., Xu, X. and Wei, D., 2013. In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food and Function, 5(1): 50-56.
- Menon, M. and Resnick, M., 2007. Urinary lithiasis: Etiology, diagnosis and medical management: 3229-3305. In: Walsh, P.C., Retik, A.B., Vaughan, E.D. and Wein, A.J., (Eds.). Campbell's Urology, Philadelphia, Saunders, 528p.
- Moron, M.E., 2014. Epistemology and lithology. Urolithiasis, 5-15.
- Mozaffarian, V., 2007. Umbelliferae: Flora of Iran (No. 54). Research Institute of Forests and Rangelands, Tehran, 596p.
- Prasobh, G.R. and Revikumar, K.G., 2012. Effect of MUSA tablet on ethylene glycol-induced urolithiasis in rats. International Journal of Pharma and Biosciences, 1251-1254.
- Selvam, R., Kalaiselvi, P., Govindaraj, A., Murugan, V.B. and Kumar, A.S., 2001. Effect of A. lanata leaf extract and Vediuppu chunnam on the urinary risk factors of calcium oxalate urolithiasis during experimental hyperoxaluria. Pharmacological Research, 43(1): 89-93.
- Shahrani, M., Pilehvarian, A., Khayri, S., Asgahri, A., Farokhi, E., Parvin, N. and Rafieian, M., 2009. Effects of Kelussia odoratissima Mozaffarian (KOM) extract on blood lipid in Balb/c mice. Journal of Shahrekord University of Medical Sciences, 8(4): 88-95.
- Skoog, D., West, D., Crouch, S. and Holler, J., 2009. Fundamentals of Analytical Chemistry. Grupo Editorial Norma, 1072p.
- Uthar, P., Mathur, K., Goyal, M. and Yadav, S., 2016. Traditional uses, phytochemistry, pharmacological properties of plant Alhagi maurorum (MEDIK.): A review. World Journal of Pharmacy and Pharmaceutical Sciences, 5(4): 682-692.
- Vahdani, R., Mehrabi, S., Malekzadeh, J., Jannesar, R., Sadeghi, H. and Shafaeifar, A., 2012. Effect of hydrophilic extract of Allium jesdianum on ethylene glycol-induced renal stone in male wistar rats. Yasuj University of Medical Sciences Journal (YUMSJ), 16(6): 557-566.
- Wu, J.C., Huang, G.R. and Cheng, J., 2012. Optimization of enzymatic hydrolysis for extraction of flavonoids from Apium graveolens L. Journal of Food Agriculture and Environment, 10(3): 182-185.
- Zargari, A., 1997. Iranian Medicinal Plants (Vol. 1). Tehran University Publication, Tehran, 976p.