The effect of carvacrol on blood pressure and blood cell number in lead-exposed rats

Zare Mehrjerdi, F.; Niknazar, S.; Shahrokhi Racini, A.

doi:10.22092/ijmapr.2018.114806.2088

Document Type : Research Paper

Authors

¹ Neurobiomedical Research Center, Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

² Hearing Disorders Research Center, Shahid Beheshti University of medical sciences, Tehran, Iran

https://doi.org/10.22092/ijmapr.2018.114806.2088

Abstract

Lead intoxication impairs oxidant/antioxidant balance that can be partially responsible for the toxic effects of lead in the various organs of body especially cardiovascular system. On the other hand, carvacrol, as major component of thyme plant, has a variety of properties including antioxidant ones. The main objective of this study was to investigate the effects of carvacrol on blood pressure and some blood parameters in lead-poisoned rats. In this study, 40 male Wistar rats were randomly divided into five groups. The first group was control, the second group was poisoned with lead, and three lead poisoned groups receiving carvacrol at doses of 25, 50 and 100 mg/kg/daily. The blood pressure was monitored weekly by tail plethysmography coupled to a computer system. At the end of experiment, blood samples were obtained to assess some hematological parameters (RBC, Hb, Hct, and WBC). The mean blood pressure in lead exposed group was significantly higher than that of control group from the 21st day of the study. Carvacrol caused a decrease in hypertension in the lead poisoned rats. This deceasing was consistent throughout the experiment. Some blood parameters (RBC, Hb, Hct, and WBC) were decreased in lead exposed rats. These changes were prevented in the lead groups receiving carvacrol. According to the result of this study, it may be concluded that carvacrol could improve some lead induced changes in the cardiovascular system.

Keywords

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Iranian Journal of Medicinal and Aromatic Plants Research

The effect of carvacrol on blood pressure and blood cell number in lead-exposed rats

References

References

Volume 34, Issue 3 - Serial Number 89
July and August 2018
Pages 457-465

The effect of carvacrol on blood pressure and blood cell number in lead-exposed rats

References

References

Volume 34, Issue 3 - Serial Number 89July and August 2018Pages 457-465

Volume 34, Issue 3 - Serial Number 89
July and August 2018
Pages 457-465