Effect of thymoquinone on improvement of lipid profile and liver enzymes in fatty liver-induced NMRI mice

Jafari Nia, L.; Haeri Rouhani, A.; Yaghmaei, P.

doi:10.22092/ijmapr.2018.116247.2187

Document Type : Research Paper

Authors

¹ M.Sc. student, Department of Animal Biology, Science and Research Campus, Islamic Azad University, Tehran, Iran

² Department of Animal Biology, Science and Research Campus, Islamic Azad University, Tehran, Iran

https://doi.org/10.22092/ijmapr.2018.116247.2187

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an increasing disease in people with urban lifestyle and this disease may progress to NASH. Thymoquinone, as a powerful antioxidant and a traditional drug, was assessed in male NMRI mice with fatty liver. In this study, 40 NMRI mice were divided into four groups: healthy control, solvent, treatment 1 and 2, treating with 5 and 10 mg/ kg of thymoquinone by i.p. for 28 days, respectively. All groups were on high fat diet for four weeks except the healthy control group. At the end of the trial, the mice tissue and serum samples were collected and then biochemical and histological parameters were assessed. Our results showed that thymoquinone significantly decreased the triglyceride, VLDL, bilirubin, phospholipid, cholesterol, HOMA, and ALT levels in treatment 2 group compared to sham group (P<0.001), insulin, AST, LDL (P<0.01), and glucose (P<0.05). The levels of ALP and leptin decreased and the HDL levels increased but not significantly. The levels of adiponectin were increased significantly (P<0.001). Histopathological assessment showed that the tissue damages were significantly improved. According to our study, thymoquinone improved the insulin resistance, lipid profile, and liver enzymes in fatty liver- nduced mice.

Keywords

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Iranian Journal of Medicinal and Aromatic Plants Research

Effect of thymoquinone on improvement of lipid profile and liver enzymes in fatty liver-induced NMRI mice

References

References

Volume 34, Issue 2 - Serial Number 88
May and June 2018
Pages 193-205

Effect of thymoquinone on improvement of lipid profile and liver enzymes in fatty liver-induced NMRI mice

References

References

Volume 34, Issue 2 - Serial Number 88May and June 2018Pages 193-205

Volume 34, Issue 2 - Serial Number 88
May and June 2018
Pages 193-205