Document Type : Research Paper

Authors

• M.R. Jalali Nadoushan ¹
• H. Jafari ²
• P. Owlia ³

¹ Assistant Professor-Pathology Department-Shahed University

² Academic Member-Pharmacology Department-Qazvin University Of Medical Sciences

³ Associate Professor-Microbiology Department-Shahed University

Abstract

Purpose:Intestinal infection by salmonellae are common. These infections induce Histopathalgic  changes in intestinal mucosa. Appropriate anti microbial therapy decreases histopathologic changes. In this research, we studied effect of agueouls garlic extract on intestinal hispathology changes.
Materials &Methods:This study has been conducted by participating 3 groups, each of included 20 rabbits. Rabbits have been infected by salmonella typhimurium orally. 48 hours after contamination , two treated groups have been taken on therapy with 20mg/kg and 40mg/kg garlic extract 3 times daily. 7 days after treatment, rabbits killed and small intestine for pathologic study exiced.
Findings:Histologic findings including edema, inflammatory cells infiltration and hyperemia shown statistical difference between groups.
Conclusion:Aqueous garlic extract decreases severity of inflammation induced by salmonella typhi murinm in intestine of rabbit. But for routine use of garlic , other studies are recommended.

Keywords

• garlic
• Salmonella
• Pathology.Antibacterial
• Anti-inflammatory