Document Type : Research Paper
Authors
1 Faculty of Medicine, Shahed University, P. O. Box 14155- 7435, Tehran, Iran
2 Research Institute of Forests and Ranglands
Abstract
Pseudomonas aeruginosa is important opportunistic pathogen and to produce widespread infections by numerous virulence factors. Treatment of Pseudomonas infection is very difficult, because resistance to antibiotics is increasing. The purpose of this study was evaluation of antimicrobial effects of extract of Ruta graveolens on P. aeruginosa (28852ATCC). MIC and MBC of extract were evaluated and change of number of bacteria in the present of 1%, 2%, 4% and 8% of R. graveolens extract was compared with the change of number of bacteria in the present of 0.00078 and 0.00156mg/ml gentamicin. The results showed that MIC and MBC of R. graveolenc extract were equal of 10% of concentration. Comparison of change of number of bacteria had shown that the effect of 8% of extract of R. graveolens after 4 h is equal of 0.00156mg/ml gentamicin after 2h.
According to the results we can probably to use of R. graveolens against Pseudomonas infections, but we need more study and research.
Keywords
)