Document Type : Research Paper
Authors
1 Ph.D., in Physiology- Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
2 Ph.D., in Physiology- Department of Physiology, School of Medicine, Iran Univ. Med. Sci., Tehran, Iran
3 Student of Medicine- School of Medicine, Shahed University, Tehran, Iran
Abstract
In the present study, the possible antinociceptive effect of methanolic seed extract of coriander was investigated in male streptozotocin-diabetic rats using standard formalin test. For this purpose, male albino wistar rats (250- 350 g) were used. They were randomly divided into three groups, i.e. control, diabetic and extract-treated diabetic. For induction of diabetes, streptozotocin (60 mg/Kg) was administered i.p. After one month, formalin test was conducted. The obtained findings demonstrated that pain sensation in the second interval (5-10 min) of the acute phase of the formalin test is
higher (P < 0.001) in comparison with control group, while a less significant difference was found between control and extract-treated diabetic group (P<0.05). On the other hand, there was no significant difference between control and extract-treated diabetic groups regarding acute and chronic phases of the formalin test. It is concluded that i.p. administration of this extract at a dose of 100 mg/Kg does not produce a significant analgesic effect in formalin test.
Keywords
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