Document Type : Research Paper
Authors
1 Microbiology group, Mashhad University of Medical Science
2 Pharmaclogy group, Mashhad University of Medical Science
3 Student of Mashhad University of Medical Science
4 PhD student of chemistry, Mashhad University
Abstract
In folk medicine, Plumbago has beenused because of antifungal property for precaution in treating mite infections. As the extract's effects of different species of Plumbago has been studied, in this research the antifungal effects of root of the European species of Plumbago was studied. For this reason methanol extract was prepared by soxhelet method and different concentrations of the extract were applied on standard and nosocomial Candida albicans and other fungus, by agar dilution and cylinder plate methods. Fungus were taken from blood, feces, spinal fluid, wound, vagina and so on. Clotrimasol was used as positive control drug. The results showed that, among the extracts, methanol extract 2% had significant antifungal activity, and in the other plates with extracts of 1.5%, 1%, 0.5% and 0/25% there was 95%, 73%, 70% and 61% inhibition of growth, respectively. Effects of methanol extract in comparison with clotrimasol were as follow; 1mg/100ml of extract was equal to 10mg/ml clotrimasol, 1.5mg/100ml of extract was equal to 20mg/ml clotrimasol, 2mg/100ml of extract was equal to 30mg/ml clotrimasol and 3mg/100ml of extract was equal to 40mg/ml clotrimasol.
Keywords
)