Document Type : Research Paper
Authors
1 Dept. of Pharmacology, Qazvin medical University
2 Dept. of Biostatistics, Qazvin University of Medical Sciences
3 Dept. of Pharmacology, Qazvin Medical University
4 Dept. of Hematology, Iran University of Medical Sciences
5 Dept. of Physiology, Shahed Univerisity
Abstract
Nowadays cardiovascular diseases are one of the most important problems for humankind. Statistically is the commonest cause of early onset death. On the other hand, the effectiveness of garlic has proved in different studies. In this study, we investigated the reducing effect of extract of garlic on positive chronotropism by adrenaline in isolated rat atrium. Rats were randomly divided to 7 groups which received adrenalin, extract of garlic (10, 20, 40mg/kg), propranolol, propranolol plus extract of garlic (40mg/kg) and control group. Atrial rate was obtained by physiographic set. The results showed that extract of garlic (40mg/kg) caused significantly reduction in rate of atrium but rate reduction with propranolol was more than one with propranolol plus extract of garlic.
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