In collaboration with Scientific Association of Iranian Medicinal Plants

Document Type : Research Paper

Authors

1 Department of Physiology/Herbal Medicine Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

2 Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

3 Paradise University, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

Abstract

Verapamil inhibits the cytosolic calcium content by blocking both activated and inactivated T-type calcium. Regarding the spasmolytic effect of materials caused by blockage of calcium channels and due to the inhibitory effect of Satureja hortensis L. on ileum smooth muscle contraction. The present study was designed to find out the synergistic effects of calcium blocker verapamil and Satureja essential oil on inhibition of cholinergic contraction in male rat’s ileum. In this study, by using an oscillographic device, the effects of different concentration of Satureja essential oil and verapamil were examined on isotonic contraction of ileum induced by acetylcholine10-4M. Our results showed that both verapamil and Satureja essential oils inhibited acetylcholine-induced contraction of ileum. In addition, their ineffective doses had synergistic spasmolytic effects, which were statistically significant (p<0.05).

Keywords

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