N. Kabiri; S. Asgary; H. Madani; P. Mahzoni; P. Rahimi
Volume 25, Issue 1 , May 2009, , Pages 29-38
Abstract
Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals ...
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Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals with the increased cardiovascular disease risk factors. This study was designed to investigate the effect of aerial parts of Hypericum perforatum L. andAmaranthus caudatus L. on the development of atherosclerosis in male hyperlipidemic rabbits. Twenty adult male rabbits were randomly divided into four groups of five and were fed for 60 days as follows: basic diet, high cholesterol, high cholesterol along withcombination Hypericum perforatumandAmaranthus caudatus(HA) extract (75mg/kg) and high cholesterol along with Lovastatin (10mg/kg). Blood samples were taken at the beginning, one month later and at the end of the study in order to measure their serum factors (cholesterol, LDL-C-C, HDL-C-C, TG). The fatty streak formation evaluated at the end of the study. The results showed that both the extract and lovastatin reduced significantly the levels of cholesterol, LDL-C-C, triglyceride and HDL-C-C) increased in comparison with high cholesterol group. Fatty streak formation in extract recipient group significantly decreasedin comparison with high cholesterol group with lovastatin. The result showed that HA significantly decreased TG, cholesterol and fatty streak formation in comparison with high cholesterol group and lovastatin. These findings suggest HA extract is more effective in decreasing the level of cardiovascular risk factors than Lovastatin in hypercholesterolemic rabbits.
M.R. Jalali Nadoushan; M.H. Ghosian Moghadam; H. Jafari; N. Fallah
Volume 24, Issue 1 , May 2008, , Pages 74-81
Abstract
One of the most important intestinals, especially in developing countries is Salmonella infection. Today, antimicrobial resistance is increased and we need new antimicrobial drugs. One of these drugs is herbal drugs. The effects of garlic extract on Salmonella typhimurium infection were studied. 60 Dutch-polish ...
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One of the most important intestinals, especially in developing countries is Salmonella infection. Today, antimicrobial resistance is increased and we need new antimicrobial drugs. One of these drugs is herbal drugs. The effects of garlic extract on Salmonella typhimurium infection were studied. 60 Dutch-polish rabbits were divided in 3 equal groups. The rabbits inoculated with 1011 colony forming unit orally. After 48 hours, two groups treated with 20 mg/kg and 40 mg/kg aqueous garlic extracts three times a day. Clinical manifestations are heart rate, weight, temperature and bowel habitus were evaluated after 24, 48, 72, 96 and 168 hours after treatment and at similar times in untreated group. Heart rate, temperature and bowel habitus status were significantly different in 3 groups and different days (p=0.000). Weight did not change significantly (p>0.05). Garlic extract decreased clinical manifestations in salmonella typhimurium infected rabbits. As a result, clinical trials for further studies.
M.R. Jalali; H. Jafari; P. Owlia; N. Fallah; A. Davati
Abstract
Salmonellosis is one of the most common infections in developing countries. Antibiotics used for management, may led not only to drug-resistance, but also to some serious complications. Since antiquity medicinal plants have been used for treatment of diseases, Garlic is one of these agents with multiple ...
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Salmonellosis is one of the most common infections in developing countries. Antibiotics used for management, may led not only to drug-resistance, but also to some serious complications. Since antiquity medicinal plants have been used for treatment of diseases, Garlic is one of these agents with multiple effects i.e. antibacterial effects. Sixty rabbits of Dutch-polish race were randomly divided in three equal groups; contaminated with no treatment as the control group, contaminated with treatment by low and high-doses of garlic aqueous extract in the other groups. All rabbits were infected with 1011 CFU of S. typhimurium fourty-eight hours after contamination, garlic aqueous extract was used in treated-groups at 20mg/kg and 40mg/kg three times a day. Stool culture is performed at first before contamination and after 24, 48, 72, 96 and 168 hours of treatment. Bacterial colony count stool showed significant statistics in different days. A significant difference was also seen in colony count of treated groups with non-treated group (p<0.001). But there was no definite difference in stool colony count of treated groups (low dose & high dose). So garlic aqueous extract has antibacterial effects on S.typhimurium. Further studies are recommended for clinical usage of this agent.
