M. Roghani; T. Baluchnejadmojarad; A. Bagheri; S.M. Atyabi
Volume 20, Issue 4 , January 2018, , Pages 477-486
Abstract
In the present study, the possible antinociceptive effect of methanolic seed extract of coriander was investigated in male streptozotocin-diabetic rats using standard formalin test. For this purpose, male albino wistar rats (250- 350 g) were used. They were randomly divided into three ...
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In the present study, the possible antinociceptive effect of methanolic seed extract of coriander was investigated in male streptozotocin-diabetic rats using standard formalin test. For this purpose, male albino wistar rats (250- 350 g) were used. They were randomly divided into three groups, i.e. control, diabetic and extract-treated diabetic. For induction of diabetes, streptozotocin (60 mg/Kg) was administered i.p. After one month, formalin test was conducted. The obtained findings demonstrated that pain sensation in the second interval (5-10 min) of the acute phase of the formalin test ishigher (P < 0.001) in comparison with control group, while a less significant difference was found between control and extract-treated diabetic group (P<0.05). On the other hand, there was no significant difference between control and extract-treated diabetic groups regarding acute and chronic phases of the formalin test. It is concluded that i.p. administration of this extract at a dose of 100 mg/Kg does not produce a significant analgesic effect in formalin test.
J. Cheraghi; A. Valadi
Abstract
Nature has served a rich repository of medicinal plants for thousands of years and impressive numbers of modern drugs have been isolated from natural sources, notably of plant origin. In this research anti-nociceptive and anti-inflammatory effects of Limonene have been been investigated. Anti-nociceptive ...
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Nature has served a rich repository of medicinal plants for thousands of years and impressive numbers of modern drugs have been isolated from natural sources, notably of plant origin. In this research anti-nociceptive and anti-inflammatory effects of Limonene have been been investigated. Anti-nociceptive activity was investigated using formalin test method. Anti-inflammation activity was investigated using xylene test method and for limonene production decantation method was used. For investigation of anti-nociceptive activity, limonene was injected to mice in three different doses as 20, 30 and 50 mg/kg. The results showed 50 mg/Kg injection had the maximum anti-nociceptive and anti-inflammatory effect.
S.H. Hejazian; A. Fattahi Bafghi; S.M. Mahdavi
Volume 25, Issue 1 , May 2009, , Pages 104-112
Abstract
One of the important aims of biological investigations is finding substances which are involved in relieving pain. Application of medicinal herbs for relieving pain is very useful. Carum copticum (L.) C. B. Clarke from Umbelliferae family has been introduced as an analgesic agent in Iranian traditional ...
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One of the important aims of biological investigations is finding substances which are involved in relieving pain. Application of medicinal herbs for relieving pain is very useful. Carum copticum (L.) C. B. Clarke from Umbelliferae family has been introduced as an analgesic agent in Iranian traditional literature which is widely used for relieving neuropathy pain and headache. This study was conducted to investigate the analgesic effect of Carum copticum fruit on formalin induced pain as compared with oil part of Carum copticum. Formalin test was used as a standard pain inducing test and the analgesic effect of intra peritoneal injection of 20ml/kg of Carum copticum extract were evaluated. Our findings showed that aqueous part of Carum copticum extract had no effect during one hour formalin test as compared with control group (P>0.05). Therefore, due to the analgesic effect of essential fatty acids and its crude extract of Carum copticum, the non analgesia property might be related to absent of oil part.
M.H. Dashti Rahmatabadi; M. Anvari; M. Rezai Sadrabadi; H. Fallah Tafti; S. Zanbagh; S. Yadegari
Volume 25, Issue 1 , May 2009, , Pages 129-138
Abstract
Nowadays, steroidal anti inflammatory and opioide analgesics are widely used to attenuate the chronic Pain. For achieving new analgesics, many investigations have been focused on understanding the antinociceptive effects of different ethnic medicinal plants. In this study, the effects of Solanum melongena ...
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Nowadays, steroidal anti inflammatory and opioide analgesics are widely used to attenuate the chronic Pain. For achieving new analgesics, many investigations have been focused on understanding the antinociceptive effects of different ethnic medicinal plants. In this study, the effects of Solanum melongena L. extract on chronic pain is assessed and compared with morphine. This study was conducted as an experimental trial on 40 male mice, equally and randomly divided in to 8 groups. 15 minutes after intra peritoneal injection of the extract, morphine or saline, 25µl of 2.5% formalin was subcutaneously injected to left hind paw of each mouse. Immediately after this injection the animals were placed under a chamber on the formalin test observational set up. Then pain scores were ascribed to each mouse according to pain intensity expression every 15 seconds during 1 hour. Our findings showed that 1000mg/kg Solanum melongena extract was analgesic in the 1st (acute) and the 2nd (chronic) phases of formalin test. This effect was more prominent during 20 to 40 min. after formalin injection and the pain score was significantly less than control (p=000). The analgesic effect of this eggplant dose, didn’t show any significant difference with 4mg/kg morphine sulfate in this time period (P=0.146). According to our findings the hydro-alcoholic extract of Solanum melongena reduces chronic pain produced by formalin injection.
S.H. Hejazian; M.H. Dashti; A. Salami
Abstract
One of the important objectives of biological investigations is to find substances which are involved in relieving pain. In this regard, application of medicinal herb are very useful. Carum copticum (L.) C. B. Clarke from Umbelliferae family has been introduced as an analgesic agent in Iranian traditional ...
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One of the important objectives of biological investigations is to find substances which are involved in relieving pain. In this regard, application of medicinal herb are very useful. Carum copticum (L.) C. B. Clarke from Umbelliferae family has been introduced as an analgesic agent in Iranian traditional literature and it is widely used to relieve neuropathic pain and headache. In the present study we conducted to investigate the analgesic effect of Carum copticum fruit on formalin induced pain as compared with morphine. In this study formalin test was used as a standard pain inducing test and the analgesic effect of intra peritoneal injection of 400mg/kg of Carum copticum extract were compared with different concentrations of morphine (1&2mg/kg). The findings show that Carum copticum has no effect on early response of pain but its effect on late phase of formalin test in chronic response of pain is significant (P=0.01). This effect was the same as 1mg/kg of morphine sulfate. According to our finding Carum copticum extract significantly reduced pain sensation in inflammatory phase of formalin test. This may be due to its essential oil which has been reported to have an analgesic and inflammatory effect.
S.H. Hejazian
Volume 23, Issue 2 , August 2007, , Pages 166-173
Abstract
The substances can produce analgesia by different receptors and the most important receptor is opiate receptor. Opiates agonists produced analgesia by binding specific G protein-coupled receptors located primarily in brain and spinal cord regions involved in the transmission and modulation of pain. Hops ...
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The substances can produce analgesia by different receptors and the most important receptor is opiate receptor. Opiates agonists produced analgesia by binding specific G protein-coupled receptors located primarily in brain and spinal cord regions involved in the transmission and modulation of pain. Hops with its scientific name Humulus Lupulus have hormonic and analgesic properties which is produced by Lopolon in plant. In this study formalin test was used as a standard pain inducing test and the analgesic effect of naloxan (5mg/kg) as an inhibitor of opiate receptor were compared to 10mg/kg of hops extract. The results show that, hops extract has no analgesic property by pretreatment of naloxan and the pain response is not significant as compared to normal saline. The pretreatment of naloxan by applying hops extract pain response is significantly increased in inflammatory phase of formalin test. This may be due to the hops arising from opiate receptors.
