E. Aghili; K. Shahanipoor; L. Amjad
Abstract
The genus Anthemis is the largest genera of the Asteraceae family. Anthemis gayana Boiss. alters the activity of liver enzymes and reduces liver enzymes and oxidative stress. Paracetamol (acetaminophen) is widely used as an antipyretic and analgesic drug, which at high levels leads to an increase in ...
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The genus Anthemis is the largest genera of the Asteraceae family. Anthemis gayana Boiss. alters the activity of liver enzymes and reduces liver enzymes and oxidative stress. Paracetamol (acetaminophen) is widely used as an antipyretic and analgesic drug, which at high levels leads to an increase in liver transaminase activity in humans and animals. The present study was aimed to determine the protective effect of Anthemis gayana methanolic extract on liver function and oxidative stress in Wistar rats treated with paracetamol. In this experiment, 40 male wistar rats were divided into eight groups of five. Animals in the first group (control) received normal saline. The second group (placebo) received paracetamol (300mg/kg). The third, fourth, and fifth group received Anthemis gayana methanolic extract (100, 200, 300mg/kg) and the sixth, seventh and eighth group received Anthemis gayana methanolic extract (100, 200, 300mg/kg) and paracetamol (300mg/kg) intraperitoneally for 30 days. AST, ALT, ALP, MDA were measured 48 hours after the last injection. The results showed a significant increase AST, ALT, ALP activity in serum in the group treated with paracetamol as compared with control group (P<0.05). The methanolic extract of Anthemis gayana showed protective effect on liver and this effect was proved by a significant decrease of ALT and MDA in serum in the group received the methanolic extract of Anthemis gayana (P<0.05). Our results clearly showed the protective effect of Anthemis gayana methanolic extract on liver enzymes and oxidative stress.
Y. Salahvarzi; A. Tehranifar; V. Jahanbakhsh
Abstract
In many countries, wastage of agricultural products is due to oxidative processes and microorganisms activity in warehouses. On the other hand, many plants are the sources of compounds with high antioxidant and antifungal activities that might be used as natural preservatives. To investigate the antioxidant ...
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In many countries, wastage of agricultural products is due to oxidative processes and microorganisms activity in warehouses. On the other hand, many plants are the sources of compounds with high antioxidant and antifungal activities that might be used as natural preservatives. To investigate the antioxidant and antifungal properties of pomegranate, a factorial experiment based on completely randomized design with 5 replications was conducted. In this study, the effect of 3 different pomegranate parts (peel, seeds and leaf) and 2 different kind of extracts (aqueous and methanolic) with 4 concentrations (0, 500, 1000 and 1500 ppm) were investigated on 2 post-harvest fungi (Alternaria citri and Aspergillus niger). According to the results, the methanolic peel extract showed the highest inhibitory effects on the mycelia growth (IMG) and spore germination (ISG) with 47.6 and 37.7 percent respectively. Also, phenolic compounds of peel extract were 1.8 times higher than that of pomegranate leaf extract. Antioxidant capacity of peel, seeds and leaf extracts was respectively 55.3, 35.7 and 16.4%. Therefore, it seems that high antifungal and antioxidant activity of peel and seeds of pomegranate are because of high percentage of phenolic compounds in these plant parts extracts.
A. Shafaghat
Abstract
One of the most important secondary metabolism products found in plants are flavonoids. They have medicinal and biological effects such as: purify blood, strengthen immune system, monitoring cholesterol level, regulate blood pressure, suppress acid secretion, prevent thrombus, suppress cytophy, antibacterial, ...
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One of the most important secondary metabolism products found in plants are flavonoids. They have medicinal and biological effects such as: purify blood, strengthen immune system, monitoring cholesterol level, regulate blood pressure, suppress acid secretion, prevent thrombus, suppress cytophy, antibacterial, prevent cancer, promote metabolism. In this study, the flavonoids and one chalcone from methanolic extract of flowers of Chrysanthemum parthenium (L.) Bernh. (syn. Tanacetum parthenium L.)(Compositae Family) were separated and purified by column chromatography and TLC methods. Kaempferol and naringenin are two flavonoids and trans- 4- ethoxy- 4'- methoxy chalcone as a chalcone compound were extracted, separated and detected by spectroscopy methods (1H-NMR, 13C-NMR, Mass and IR). Investigation of antioxidant activity included free radical scavenging activity towards 2, 2-diphenyl-1-pycrylhydrazile (DPPH) radicals. Methanolic extract of flowers of Tanacetum parthenium showed free radical scavenging activity.
M.M. Attarpour Yazdi; M. Kamalinejad; N.S. Falvaei Koochak; S. Mansouri
Abstract
Burn wound is suitable site for incidence of resistant infections. Thus, the research for finding effective drugs against this problem is necessary. Medicinal herbs with antimicrobial activity have important role in traditional medicine. The purpose of this study was to determine antibacterial activity ...
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Burn wound is suitable site for incidence of resistant infections. Thus, the research for finding effective drugs against this problem is necessary. Medicinal herbs with antimicrobial activity have important role in traditional medicine. The purpose of this study was to determine antibacterial activity of methanolic extract of Terminalia catappa L. fruitagainst bacteria isolated from burn wound infections and to compare with effects of some selected antibiotics. First, a sample of methanolic extract of the Terminalia catappa fruit was prepared and then its antibacterial activity against 8 bacteria from 100 samples of burn wound infection were evaluated by well diffusion method at concentration of 40 mg/ml and then Agar Serial Dilution method in the range of 0.039-20mg/ml. Also, the MIC (Minimal Inhibitory Concentration) of extract was determined. The antibacterial activity of selective antibiotics was tested by disk diffusion method. The onava test was used to compare the results. The results from the antibacterial tests demonstrated that the Terminalia catappa methanolic extract had been effected against all of Pseudomonas aeruginosa, Acinetobacter spp. and more than 80% of Staphylococcus aureus/epidermidis/saprophyticus, and against 50% of Escherichia coli. The MIC of the extract against all the sensitive cases was 20 mg/ml. The bacteria were often resistant to selective drugs .There was significant difference between the effects of plant and antibiotics on Pseudomonas aeruginosa (P<0/001), Acinetobacter spp. (P<0/05) and Staphylococcus cases (P<0/05). This study demonstrated that methanolic extract of Terminalia catappa have excellent antibacterial activity against most of bacteria isolated from burn wound infections and its effect is better than selective antibiotics. However, we need more in vitro and in vivo investigation.
