N. Kabiri; S. Asgary; P. Rahimi
Abstract
Regression and suppression of atherosclerotic lesion may be a realistic goal in some patients. Antioxidants and hypolipidemic agents suppress the development of hypercholesterolemic atherosclerosis and induce regression of atherosclerosis. In this study, the serum lipid and atherosclerotic lesions following ...
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Regression and suppression of atherosclerotic lesion may be a realistic goal in some patients. Antioxidants and hypolipidemic agents suppress the development of hypercholesterolemic atherosclerosis and induce regression of atherosclerosis. In this study, the serum lipid and atherosclerotic lesions following the intake of Hypericum perforatum L. on regression in hypercholesterolemic rabbits were investigated. Rabbits were assigned to four groups as follows: Group I control diet (75 days); Group II 1% cholesterol diet (75 days); Group III 1% cholesterol diet (45 days) followed by regular diet(30 days); Group IV 1% cholesterol diet (45 days) followed by regular diet and HPL (30 days). Blood samples were collected at baseline and after 45 days and 75 days for measurement of serum lipids. At the end of the protocol, the aorta was removed for assessment of atherosclerotic plaques. Our results showed that plasma total cholesterol, TG, LDL-C concentrations and AI, decreased, and the plasma HDL cholesterol concentration increased in Groups III– ΙV. The decrease of serum Lipids and atherosclerotic lesions in Group IV was more compared to that of Group III in regression period. The reduction in atherosclerotic lesions was associated with a reduction in oxidative stress. These results suggest that regular diet following a high cholesterol diet accelerates atherosclerosis in spite of a decrease in serum lipids; According to the results, HPL treatment prevents the progression of atherosclerosis following a high cholesterol diet probably associated with a reduction of risk factors and antioxidant mechanism.
N. Kabiri; S. Asgary; H. Madani; P. Mahzoni; P. Rahimi
Volume 25, Issue 1 , May 2009, , Pages 29-38
Abstract
Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals ...
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Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals with the increased cardiovascular disease risk factors. This study was designed to investigate the effect of aerial parts of Hypericum perforatum L. andAmaranthus caudatus L. on the development of atherosclerosis in male hyperlipidemic rabbits. Twenty adult male rabbits were randomly divided into four groups of five and were fed for 60 days as follows: basic diet, high cholesterol, high cholesterol along withcombination Hypericum perforatumandAmaranthus caudatus(HA) extract (75mg/kg) and high cholesterol along with Lovastatin (10mg/kg). Blood samples were taken at the beginning, one month later and at the end of the study in order to measure their serum factors (cholesterol, LDL-C-C, HDL-C-C, TG). The fatty streak formation evaluated at the end of the study. The results showed that both the extract and lovastatin reduced significantly the levels of cholesterol, LDL-C-C, triglyceride and HDL-C-C) increased in comparison with high cholesterol group. Fatty streak formation in extract recipient group significantly decreasedin comparison with high cholesterol group with lovastatin. The result showed that HA significantly decreased TG, cholesterol and fatty streak formation in comparison with high cholesterol group and lovastatin. These findings suggest HA extract is more effective in decreasing the level of cardiovascular risk factors than Lovastatin in hypercholesterolemic rabbits.
S. Asgary; N. Kabiri; H. Madani; P. Mahzoni; P. Rahimi
Volume 24, Issue 3 , November 2008, , Pages 353-362
Abstract
In this study, anti atherosclerosis effect of aerial parts extract of Amaranthus caudatus L. on rabbits was studied. Twenty male New Zealand rabbits were randomly divided into four groups of five and were fed for 60 days as follows: standard diet, standard diet and cholesterol, standard diet and Amaranthus ...
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In this study, anti atherosclerosis effect of aerial parts extract of Amaranthus caudatus L. on rabbits was studied. Twenty male New Zealand rabbits were randomly divided into four groups of five and were fed for 60 days as follows: standard diet, standard diet and cholesterol, standard diet and Amaranthus caudatus extract (150 mg/kg daily), standard diet and Amaranthus caudatus extract (150 mg/kg daily) and cholesterol. Prior to the beginning of diets and at the 60th day of experiment, the biochemical factors were measured. The fatty streak formation was evaluated at the end of the study. Rabbits fed high cholesterol diet with Amaranthus Caudatus extract cholesterol, LDL-C, triglyceride, apo-lipoprotein B (apoB), CRP, atherogenic index (AI) significantly decreased and HDL-C and apo-lipoprotein A (apoA) increased compared to with high cholesterol group. Also lesion severity, in extract recipient group, significantly decreased. Amaranthus caudatus extract by decreasing serum lipoproteins and apo B, is one of the most important new risk factors of cardiovascular diseases and by decreasing inflammatory factors prevent atherosclerosis.
N. Jafari Dinani; S. Asgary; H. Madani; Gh. Naderi; P. Mahzoni
Volume 23, Issue 1 , May 2007, , Pages 1-12
Abstract
Atherosclerosis occurs principally in medium and large arteries and is a leading cause of cardiovascular disease. Epidemiologic study indicates that coronary heart disease and atherosclerosis is less in societies which use herbal medicines. Glycyrrhiza glabra is an herb of Papilionaceae family which ...
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Atherosclerosis occurs principally in medium and large arteries and is a leading cause of cardiovascular disease. Epidemiologic study indicates that coronary heart disease and atherosclerosis is less in societies which use herbal medicines. Glycyrrhiza glabra is an herb of Papilionaceae family which contains hypolipidemic compounds and flavonoids with high antioxidant properties. This study was conducted to determine the effect of Glycyrrhiza glabra extract on blood lipid levels and atherosclerosis in rabbits fed with high cholesterol diet. Fifteen male rabbits were randomly divided into three groups, normal diet group, highcholesterolemic control group (1% cholesterol) and high-cholesterol + Glycyrrhiza glabra group (50 mg/kg body weight every other day). The concentration of total cholesterol (TC), LDL cholesterol, triglycerides (TG) and HDL cholesterol were determined in rabbits in the beginning of experiment, and in the end of the first and second month of the study. In the end of the experimental period the rabbits were killed having overdose chloroform and their aortas were removed for assessing atherosclerotic plaques. Results showed that Glycyrrhiza glabra decreased TC, LDL and TG levels and increased HDL, significantly. The lesion atherosclerotic significantly reduced in high-cholesterol + Glycyrrhiza glabra group as compared to highcholesterolemic control group. It could be suggested that the Glycyrrhiza glabra extract can effectively prevent the progress of atherosclerosis and extensive studies are needed to investigate the effect of Glycyrrhiza glabra in prevention and treatment of atherosclerosis.
S. Asgary; H. Madani; P. Mahzoni; N. Jafari; Gh. Naderi
Volume 22, Issue 4 , February 2007, , Pages 303-314
Abstract
Coronary heart disease (CHD) is invariably the most frequent cause of death in most of the west countries. Atherosclerosis which is the most common risk factor for CHD caused by a gradual deposition of fats and lipids in muscular arteries. Many species of Artemisia from Compositeae family have hypolipidemic ...
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Coronary heart disease (CHD) is invariably the most frequent cause of death in most of the west countries. Atherosclerosis which is the most common risk factor for CHD caused by a gradual deposition of fats and lipids in muscular arteries. Many species of Artemisia from Compositeae family have hypolipidemic and antioxidative properties. The objective of this study was to determine the effect of Artemisia sieberi extract on blood lipids and development of atherosclerosis in rabbits fed by a high cholesterol diet. For this objective 15 male rabbits were randomly divided in three groups (normal diet, hypercholesterolemic diet (HCD) and HCD + 100 mg/kg body weight Artemisia sieberi extract). Total cholesterol (TC), LDL cholesterol, triglycerides (TG) and HDL cholesterol were measured before starting and after 1st and 2nd months of experimental period. After two months, rabbits were killed following chloroform over dose and their aortas were removed for assessment of atherosclerotic plaques. The results indicate that Artemisia sieberi significantly reduces the levels of TC, LDL, TG and TC/HDL and significantly increase the level of HDL. The atherosclerotic plaque formation was significantly reduced in Artemisia sieberi group as compared to the control hypercholesterolemic group.