E. Aghili; K. Shahanipoor; L. Amjad
Abstract
The genus Anthemis is the largest genera of the Asteraceae family. Anthemis gayana Boiss. alters the activity of liver enzymes and reduces liver enzymes and oxidative stress. Paracetamol (acetaminophen) is widely used as an antipyretic and analgesic drug, which at high levels leads to an increase in ...
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The genus Anthemis is the largest genera of the Asteraceae family. Anthemis gayana Boiss. alters the activity of liver enzymes and reduces liver enzymes and oxidative stress. Paracetamol (acetaminophen) is widely used as an antipyretic and analgesic drug, which at high levels leads to an increase in liver transaminase activity in humans and animals. The present study was aimed to determine the protective effect of Anthemis gayana methanolic extract on liver function and oxidative stress in Wistar rats treated with paracetamol. In this experiment, 40 male wistar rats were divided into eight groups of five. Animals in the first group (control) received normal saline. The second group (placebo) received paracetamol (300mg/kg). The third, fourth, and fifth group received Anthemis gayana methanolic extract (100, 200, 300mg/kg) and the sixth, seventh and eighth group received Anthemis gayana methanolic extract (100, 200, 300mg/kg) and paracetamol (300mg/kg) intraperitoneally for 30 days. AST, ALT, ALP, MDA were measured 48 hours after the last injection. The results showed a significant increase AST, ALT, ALP activity in serum in the group treated with paracetamol as compared with control group (P<0.05). The methanolic extract of Anthemis gayana showed protective effect on liver and this effect was proved by a significant decrease of ALT and MDA in serum in the group received the methanolic extract of Anthemis gayana (P<0.05). Our results clearly showed the protective effect of Anthemis gayana methanolic extract on liver enzymes and oxidative stress.
M.R. Shahraki; H. Mirshekari; A.R Shahraki; E. Shahraki
Abstract
Since Ocimum basilicumL. is used as a traditional herbal medicine, this study was carried out to evaluate the effect of aqueous and metanolic extract of Ocimum basilicum leaf on blood glucose, lipid profiles and liver enzymes in fructose-fed male rats. The experiment was performed on 32 Wistar-Albino ...
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Since Ocimum basilicumL. is used as a traditional herbal medicine, this study was carried out to evaluate the effect of aqueous and metanolic extract of Ocimum basilicum leaf on blood glucose, lipid profiles and liver enzymes in fructose-fed male rats. The experiment was performed on 32 Wistar-Albino rats including one control group (A) and three tests groups (B, C and D). Test groups consumed fructose-enriched water and received zero and 20mg/kg aqueous and metabolic extract daily and respectively for 60 days but control group consumed tap water in treatment duration. At the end, serum glucose, insulin, liver enzymes and lipid profile were measured. The obtained data were analyzed by ANOVA and Tukey tests. Results were expressed as mean ± SE and significant differences were found at 0.05% level of probability. Our findings showed that insulin resistance index, insulin and FBS in tests groups significantly increased compared with those of group A; however, serum insulin value in group D significantly increased compared with that of group B and C. On the other hand, AST (aspartate aminotransfrase) and ALT (alanine amino transferase) values in group D significantly decreased compared with those of the B and C groups. Also, the value of LDL in group C was significantly lower in comparison to other test groups. The results of this study showed that consumption of Ocimum basilicumleaf extract had an effect on LDL and liver enzymes in fructose-fed male rats.