Iranian Journal of Medicinal and Aromatic Plants Research

The effects of hydroalcoholic extracts of dill (Anethum graveolens L.) and artichoke (Cynara scolymus L.) against type 1 diabetes mellitus

N. Ahmadi Mahmoodabadi

Volume 24, Issue 3 , November 2008, , Pages 333-341

Abstract

This study investigated human type-1 diabetes mellitus in rats with use using alloxan monohydrate. Then, the effects of hydroalcoholic extracts of dill and artichoke on biochemical factors for example glucose, cholesterol, triglyceride, VLDL-C, HDL-C and LDL-C were studied and compared. 25 adult male ... Read More

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Hypoglycemic and hypolipidemic effect of hydroalcoholic Cynara scolymus L. extract in alloxan monohydrate-induced diabetic rats to compare with glibenclamide

N. Ahmadi Mahmoodabadi; H. Madani; P. Mahzooni

Volume 24, Issue 2 , August 2008, , Pages 148-161

Abstract

Artichoke with the scientific name of Cynara scolymus is a plantfromCompositeae family. In this research, the effect of hydroalcoholic extract of artichoke on the changes of serum glucose, lipids and lipoproteins in alloxan monohydrate-induced diabetic rats was investigated. Also, the effect of extract ... Read More Artichoke with the scientific name of Cynara scolymus is a plantfromCompositeae family. In this research, the effect of hydroalcoholic extract of artichoke on the changes of serum glucose, lipids and lipoproteins in alloxan monohydrate-induced diabetic rats was investigated. Also, the effect of extract on damaged pancreatic tissue was investigated and was compared with glybenclamide as a chemical drug. Twenty adult male rats, weighing 200-250 gr, were used in four groups of five each (control, diabetic, diabetic+glibenclamide, diabetic + artichoke extract). The first group (control), received serum physiology equal to injecting material volume. Second group (diabetic), received 120 mg/kgbw alloxan monohydrate. Third group (diabetic + glibenclamide) received 0/5 mg/kg bw glibenclamide in addition to the similar treatment with second group. Fourth group (diabetic + Cynara scolymus) at first, became diabetic by alloxan monohydrate injection, then they received 300 mg/kgbw hydroalcoholic plant extract. Prescribing materials in all groups was done as interaperitoneal injection (IP). The results from statistical analysis show that Cynara scolymus extract reduce significantly the rate of glucose, cholesterol, triglyceride, VLDL and LDL than diabetic group (P</0 05). Also, artichoke which decreased rate of glucose was similar to glybenclamide group, but comparing to control group, it has significant difference. The effect of this plant on other investigating factors was similar to glybenclamid and control groups (P>/0 05). The results of Histologic studies confirmed this part of research. On the base of histologic results, extract have a significant effect on increasing the size of pancreatic islets, number of islet cells and cell proliferation than diabetic group. This research suggested that hydroalcoholic extract of Cynara scolymus has a significant effect on decreasing the blood sugar, serum lipids and lipoproteins than diabetic rats. Also the effect of extract in repairing damaged pancreatic tissue was confirmed.

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Author = N. Ahmadi Mahmoodabadi

The effects of hydroalcoholic extracts of dill (Anethum graveolens L.) and artichoke (Cynara scolymus L.) against type 1 diabetes mellitus

Abstract

Hypoglycemic and hypolipidemic effect of hydroalcoholic Cynara scolymus L. extract in alloxan monohydrate-induced diabetic rats to compare with glibenclamide

Abstract