A. Rahmanpour; M. Nasiri; M.R. Farahpour
Abstract
Wound infections caused by Candida albicans, have substantially grown in recent years. The lack of easy access, medicine costliness, side effects, and development of the pharmaceutical resistance resulted in using biological materials as an alternative. Thymus vulgaris L. is one of the antimicrobial ...
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Wound infections caused by Candida albicans, have substantially grown in recent years. The lack of easy access, medicine costliness, side effects, and development of the pharmaceutical resistance resulted in using biological materials as an alternative. Thymus vulgaris L. is one of the antimicrobial properties of biological materials, whose effectiveness has been proved from a long time ago. This study analyzed the local effects of Thymus essential oil on healing the cutaneous incisional wounds in the case of rats infected with Candida albicans. In this experiment, carried out on 36 Wistar male rats with an average weight of 210±10 g, after general anesthesia and making a 1.5×1.5 cm square wound between the shoulder area, 0.5 ml. of the yeast suspension containing 1.5×106 CFU/ml Candida albicans was applied to the wound(s). Then, in three groups of 12 (to control with 3 percent and 1.5 percent local ointments), the rats were randomly distributed into 4 subgroups of 3 animals (each group was sampled on different days). During the experiment, in order to assess the histopathology and yeast count, at the end of 4th, 8th, 12th, 16th, and 20th days, samples were taken by a special biopsy punch. According to the result drawn from this experiment, and regarding the effects of 3 percent and 1.5 percent ointments, there was not a conspicuous dissimilarity in reducing the Candida albicans yeast count, but in comparison with the control group, this dissimilarity was noticeably meaningful (P<0.001). Moreover, according to the histopathological studies, both ointments showed significantly remarkable results in terms of reduced blood vessels and mononuclear cells, increased fibroblast cells, and increased number of macrophages in comparison with the control group. Overall, since the 3 percent ointment had achievements similar to the 1.5 percent one, and mostly well-achieved as compared with the other (two) groups, it (the 3 percent ointment) would be the final choice to local usage in the process of healing and reducing of Candida albicans infections.
S. Hesaraki; M.R. Farahpour; B. Yahyaei
Abstract
Wound is an inevitable event in life, occurring due to microbial infection or physical or chemical damage. The present study was conducted in order to compare the effect of Ceylon cinnamon extract and flaxseed oil on the healing of wounds induced in rat. Thirty-two rats were divided into four groups. ...
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Wound is an inevitable event in life, occurring due to microbial infection or physical or chemical damage. The present study was conducted in order to compare the effect of Ceylon cinnamon extract and flaxseed oil on the healing of wounds induced in rat. Thirty-two rats were divided into four groups. The wound healing process was evaluated for groups related to Ceylon cinnamon ethanolic extract (3%) and flaxseed oil at a concentration of 3% on days 3, 7, 14 and 21. In addition, one group received no treatment as control, and one group received the vaseline eucerin ointment as reference standard. The results showed that Ceylon cinnamon extract and flaxseedoil were effective in accelerating the wounds healing process and, in particular, increased epithelization rate in the treatment groups compared to the other groups, so that the size of the wound area in the Ceylon cinnamon group, flaxseedoil group, placebo group and the control group on day 21 were calculated to be 2.6±0.4, 3.72±0.05, 5.01±0.09 and 5.3±0.07, respectively. Comparative evaluation of this study showed that Ceylon cinnamon was more effective in accelerating the closure of wound as compared with flaxseed oil.
N. Moezzi; H. Najafzadeh Varzi; S. Shirali
Abstract
Decrease of collateral effect of wound repairing is one of the important objects of radiology and surgery studies. Identification of the effective, cheap and available drugs that have public grace is necessary. Whereas the Oleaster (Elaeagnus angustifolia L.) extract and Henna (Lowsonia intermis L.) ...
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Decrease of collateral effect of wound repairing is one of the important objects of radiology and surgery studies. Identification of the effective, cheap and available drugs that have public grace is necessary. Whereas the Oleaster (Elaeagnus angustifolia L.) extract and Henna (Lowsonia intermis L.) had anti-inflammatory effect in previous studies, so, in this study we compared their effect with silver sulfadiazine in wound healing. Female rats divided to four groups (four rats in each group). Rats anesthetized with standard combination of Ketamin-HCl and Acepromazine and incised with surgical blade on the mid dorsal line, then sutured with nylon suture. The wound was six centimeter length and five knobs with one centimeter distances applied. The wound length measured every day until complete recovery. Five hundred milligrams of oleaster extract, Henna paste and silver sulfadiazine ointment applied on wounds every day and one group didn't have any drugs as a control group. Average of repairing percent in first week in sulfadiazine and Oleaster groups were 90%, whereas this was 70% for henna group and 50% for control group. Complete wound healing in control groups; Henna, Oleaster and Sulfadiazine were observed in 13, 12, 10 and 8 days after surgery, consecutively. As a result, Olester extract can repair the wound same as silver sulfadiazine, whereas the Henna did not show the same effect in that definite time.
A. Siami; R. Heidari; R. Pakbaz; M. Aghazade
Abstract
Throuyg the 4 genotypes studied of oak (Quercus) are considered that the in Q. infectoria galls has the highest amount of tannin. We measured the amount of tannins as a group of Phenolic compound by spectrophotometry with comparing by standard solution at 550 nanometer light wave. Surgical complication ...
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Throuyg the 4 genotypes studied of oak (Quercus) are considered that the in Q. infectoria galls has the highest amount of tannin. We measured the amount of tannins as a group of Phenolic compound by spectrophotometry with comparing by standard solution at 550 nanometer light wave. Surgical complication and healingby the tannin powder spray examinated in the five group of rat after 6,12,24,72,144 hours. The result indicate that the best time of tannin using for experimental wound healing is 144 hours, by histopatological study.
