N. Kabiri; S. Asgary; P. Rahimi
Abstract
Regression and suppression of atherosclerotic lesion may be a realistic goal in some patients. Antioxidants and hypolipidemic agents suppress the development of hypercholesterolemic atherosclerosis and induce regression of atherosclerosis. In this study, the serum lipid and atherosclerotic lesions following ...
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Regression and suppression of atherosclerotic lesion may be a realistic goal in some patients. Antioxidants and hypolipidemic agents suppress the development of hypercholesterolemic atherosclerosis and induce regression of atherosclerosis. In this study, the serum lipid and atherosclerotic lesions following the intake of Hypericum perforatum L. on regression in hypercholesterolemic rabbits were investigated. Rabbits were assigned to four groups as follows: Group I control diet (75 days); Group II 1% cholesterol diet (75 days); Group III 1% cholesterol diet (45 days) followed by regular diet(30 days); Group IV 1% cholesterol diet (45 days) followed by regular diet and HPL (30 days). Blood samples were collected at baseline and after 45 days and 75 days for measurement of serum lipids. At the end of the protocol, the aorta was removed for assessment of atherosclerotic plaques. Our results showed that plasma total cholesterol, TG, LDL-C concentrations and AI, decreased, and the plasma HDL cholesterol concentration increased in Groups III– ΙV. The decrease of serum Lipids and atherosclerotic lesions in Group IV was more compared to that of Group III in regression period. The reduction in atherosclerotic lesions was associated with a reduction in oxidative stress. These results suggest that regular diet following a high cholesterol diet accelerates atherosclerosis in spite of a decrease in serum lipids; According to the results, HPL treatment prevents the progression of atherosclerosis following a high cholesterol diet probably associated with a reduction of risk factors and antioxidant mechanism.
N. Kabiri; S. Asgary; P. Rahimi
Abstract
Hypercholesterolemia, cholesterol-enriched diet and oxidative stress may cause an increase in serum total cholesterol (TC) levels resulting in development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging free radicals. Amaranthus caudatus L. is a lipid-lowering and ...
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Hypercholesterolemia, cholesterol-enriched diet and oxidative stress may cause an increase in serum total cholesterol (TC) levels resulting in development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging free radicals. Amaranthus caudatus L. is a lipid-lowering and antioxidant agent. The objectives of this study were to determine the effect of Amaranthus caudatus L. in reduction of some risk factor for atherosclerosis associated with reduction of oxidative stress. rabbits were assigned to four groups: Group I, regular diet (control); Group II, 1% cholesterol diet for 75 days; Group III, 1% cholesterol diet (45 days) followed by regular diet(30 days); Group IV, 1% cholesterol diet (45 days) followed by regular diet and Amaranthus caudatus (30 days) (150 mg·kg body wt). Blood samples were collected from rabbits before (0 time) and after 45 days and 75 days of experimental diets for measurement of apolipoproteinB (apoB), malondialdehyde (MDA), apolipoproteinA (apoA) and OX-LDL. The results showed that application of Amaranthus caudatus for 30 days caused a significant decrease in apolipoproteinB (apoB), malondialdehyde (MDA) and OX-LDL. However apolipoproteinA (apoA) increased significantly. Whereas, no significant decrease of risk factors was observed in animals received only normal diet. Consequently, these effects of Amaranthus are associated with reductions in oxidative stress probably due to the antiatherogenic effects and it could be considered as an important diet in regression of atherosclerosis.
N. Kabiri; S. Asgary; H. Madani; P. Rahimi
Volume 24, Issue 3 , November 2008, , Pages 304-312
Abstract
Cardiovascular diseases and atherosclerosis are the leading cause of mortality and morbidity around the world. Inflammation and coagulation are two important risk factors of cardiovascular disease. In this study, the effect of the concurrent hydroalcoholic extracts of Hypericum perforatumL. and Amaranthus ...
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Cardiovascular diseases and atherosclerosis are the leading cause of mortality and morbidity around the world. Inflammation and coagulation are two important risk factors of cardiovascular disease. In this study, the effect of the concurrent hydroalcoholic extracts of Hypericum perforatumL. and Amaranthus caudatus L. on inflammatory and coagulation factors in hypercholesterolemic rabbits was studied and its effect was compared with lovastatin. Twenty adult male Newzeland rabbits were randomly divided into four groups of five and were fed for 60 days as follows: basic diet, high cholesterol, high cholesterol along withcombination of Hypericum and Amaranth (HA) extract (75mg/kg) and high cholesterol along with Lovastatin (10mg/kg). Blood samples were taken at the beginning, one month later and at the end of the study in order to measure their serum factors. The result showed that both the extract and lovastatin reduced significantly CRP, white blood cell, fibrinogen and platelet. Therefore Hypericum and Amaranthus by decreasing inflammation and coagulation risk factor prevent atherosclerosis also results showed that above extract is more effective to decrease Cardiovascular risk factor than lovastatin.
