N. Kabiri; S. Asgary; P. Rahimi
Abstract
Hypercholesterolemia, cholesterol-enriched diet and oxidative stress may cause an increase in serum total cholesterol (TC) levels resulting in development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging free radicals. Amaranthus caudatus L. is a lipid-lowering and ...
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Hypercholesterolemia, cholesterol-enriched diet and oxidative stress may cause an increase in serum total cholesterol (TC) levels resulting in development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging free radicals. Amaranthus caudatus L. is a lipid-lowering and antioxidant agent. The objectives of this study were to determine the effect of Amaranthus caudatus L. in reduction of some risk factor for atherosclerosis associated with reduction of oxidative stress. rabbits were assigned to four groups: Group I, regular diet (control); Group II, 1% cholesterol diet for 75 days; Group III, 1% cholesterol diet (45 days) followed by regular diet(30 days); Group IV, 1% cholesterol diet (45 days) followed by regular diet and Amaranthus caudatus (30 days) (150 mg·kg body wt). Blood samples were collected from rabbits before (0 time) and after 45 days and 75 days of experimental diets for measurement of apolipoproteinB (apoB), malondialdehyde (MDA), apolipoproteinA (apoA) and OX-LDL. The results showed that application of Amaranthus caudatus for 30 days caused a significant decrease in apolipoproteinB (apoB), malondialdehyde (MDA) and OX-LDL. However apolipoproteinA (apoA) increased significantly. Whereas, no significant decrease of risk factors was observed in animals received only normal diet. Consequently, these effects of Amaranthus are associated with reductions in oxidative stress probably due to the antiatherogenic effects and it could be considered as an important diet in regression of atherosclerosis.
N. Kabiri; S. Asgary; H. Madani; P. Mahzoni; P. Rahimi
Volume 25, Issue 1 , May 2009, , Pages 29-38
Abstract
Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals ...
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Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals with the increased cardiovascular disease risk factors. This study was designed to investigate the effect of aerial parts of Hypericum perforatum L. andAmaranthus caudatus L. on the development of atherosclerosis in male hyperlipidemic rabbits. Twenty adult male rabbits were randomly divided into four groups of five and were fed for 60 days as follows: basic diet, high cholesterol, high cholesterol along withcombination Hypericum perforatumandAmaranthus caudatus(HA) extract (75mg/kg) and high cholesterol along with Lovastatin (10mg/kg). Blood samples were taken at the beginning, one month later and at the end of the study in order to measure their serum factors (cholesterol, LDL-C-C, HDL-C-C, TG). The fatty streak formation evaluated at the end of the study. The results showed that both the extract and lovastatin reduced significantly the levels of cholesterol, LDL-C-C, triglyceride and HDL-C-C) increased in comparison with high cholesterol group. Fatty streak formation in extract recipient group significantly decreasedin comparison with high cholesterol group with lovastatin. The result showed that HA significantly decreased TG, cholesterol and fatty streak formation in comparison with high cholesterol group and lovastatin. These findings suggest HA extract is more effective in decreasing the level of cardiovascular risk factors than Lovastatin in hypercholesterolemic rabbits.
S. Asgary; N. Kabiri; H. Madani; P. Mahzoni; P. Rahimi
Volume 24, Issue 3 , November 2008, , Pages 353-362
Abstract
In this study, anti atherosclerosis effect of aerial parts extract of Amaranthus caudatus L. on rabbits was studied. Twenty male New Zealand rabbits were randomly divided into four groups of five and were fed for 60 days as follows: standard diet, standard diet and cholesterol, standard diet and Amaranthus ...
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In this study, anti atherosclerosis effect of aerial parts extract of Amaranthus caudatus L. on rabbits was studied. Twenty male New Zealand rabbits were randomly divided into four groups of five and were fed for 60 days as follows: standard diet, standard diet and cholesterol, standard diet and Amaranthus caudatus extract (150 mg/kg daily), standard diet and Amaranthus caudatus extract (150 mg/kg daily) and cholesterol. Prior to the beginning of diets and at the 60th day of experiment, the biochemical factors were measured. The fatty streak formation was evaluated at the end of the study. Rabbits fed high cholesterol diet with Amaranthus Caudatus extract cholesterol, LDL-C, triglyceride, apo-lipoprotein B (apoB), CRP, atherogenic index (AI) significantly decreased and HDL-C and apo-lipoprotein A (apoA) increased compared to with high cholesterol group. Also lesion severity, in extract recipient group, significantly decreased. Amaranthus caudatus extract by decreasing serum lipoproteins and apo B, is one of the most important new risk factors of cardiovascular diseases and by decreasing inflammatory factors prevent atherosclerosis.
